Protein kinase C theta type

URI: https://gptkb.org/entity/Protein_kinase_C_theta_type
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:PKC-theta
nPKC-theta
gptkbp:associatedWith gptkb:cancer
autoimmune diseases
gptkbp:biologicalProcess protein serine/threonine kinase activity
gptkbp:discoveredBy gptkb:Yasutomi_Nishizuka
gptkbp:encodedBy gptkb:PRKCQ_gene
gptkbp:Entrez_Gene_ID 5588
gptkbp:enzymeClassification EC 2.7.11.13
gptkbp:expressedIn T lymphocytes
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function signal transduction
T cell activation
gptkbp:GOID gptkb:GO:0004697
https://www.w3.org/2000/01/rdf-schema#label Protein kinase C theta type
gptkbp:inhibitedBy rottlerin
sotrastaurin
gptkbp:interactsWith gptkb:Vav1
gptkb:CD28
gptkb:Lck
gptkbp:involvedIn gptkb:NF-kappaB_signaling_pathway
immune response
gptkbp:locatedOnChromosome 10p15
gptkbp:location gptkb:cytoplasm
gptkb:plasma_membrane
gptkbp:molecularWeight 82 kDa
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB 2JED
gptkbp:phosphorylates gptkb:NFAT
gptkb:IKK_complex
CARD11
gptkbp:postTranslationalModification phosphorylation
ubiquitination
gptkbp:regulates T cell receptor signaling
gptkbp:reviewedBy gptkb:GeneCards
gptkb:NCBI_Gene
gptkb:UniProtKB/Swiss-Prot
gptkbp:role multiple sclerosis
rheumatoid arthritis
T cell lymphoma
gptkbp:species vertebrates
gptkbp:structure contains kinase domain
contains C1 and C2 domains
gptkbp:subcellularDistribution gptkb:immunological_synapse
gptkbp:UniProtID gptkb:Q04759
gptkbp:bfsParent gptkb:PKC_theta
gptkbp:bfsLayer 7