Protein Tyrosine Phosphatase gene family

GPTKB entity

Predicate	Object
gptkbp:instanceOf	gptkb:protein
gptkbp:discoveredBy	gptkb:Edwin_G._Krebs gptkb:Edmond_H._Fischer
gptkbp:encodes	protein tyrosine phosphatase enzymes
gptkbp:firstDescribed	1988
gptkbp:foundIn	gptkb:Eukaryotes
gptkbp:function	dephosphorylation of tyrosine residues
gptkbp:hasBiologicalActivity	gptkb:EC_3.1.3.16 EC 3.1.3.48
gptkbp:hasMember	gptkb:PTPN11 gptkb:SHP2 gptkb:PTPN1 gptkb:PTPN2 gptkb:PTPRC gptkb:PTPRD gptkb:PTPRF gptkb:PTPRG gptkb:PTPRT gptkb:PTPRZ1 gptkb:DUSP1 gptkb:DUSP6 SHP1
https://www.w3.org/2000/01/rdf-schema#label	Protein Tyrosine Phosphatase gene family
gptkbp:involvedIn	cell differentiation cell signaling cell growth regulation oncogenesis
gptkbp:mutationAssociatedWith	gptkb:cancer gptkb:diabetes autoimmune diseases developmental disorders
gptkbp:orthologIn	gptkb:yeast invertebrates mammals plants
gptkbp:regulates	immune response protein phosphorylation cellular communication signal transduction pathways metabolic processes
gptkbp:subfamily	Dual-specificity phosphatases Class I PTPs Class II PTPs Class III PTPs
gptkbp:target	small molecule inhibitors therapeutic drugs
gptkbp:bfsParent	gptkb:PTP_gene_family
gptkbp:bfsLayer	7