Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:alternativeName |
gptkb:PTPN11
Tyrosine-protein phosphatase non-receptor type 11 |
| gptkbp:associatedWith |
gptkb:juvenile_myelomonocytic_leukemia
gptkb:Noonan_syndrome leukemia |
| gptkbp:discoveredBy |
Nicholas K. Tonks
|
| gptkbp:domain |
gptkb:protein_tyrosine_phosphatase_domain
SH2 domain |
| gptkbp:encodedBy |
gptkb:PTPN11_gene
|
| gptkbp:function |
gptkb:protein_tyrosine_phosphatase
|
| https://www.w3.org/2000/01/rdf-schema#label |
SHP2
|
| gptkbp:involvedIn |
gptkb:RAS/MAPK_pathway
cell differentiation cell migration cell signaling cell growth regulation hematopoiesis |
| gptkbp:location |
gptkb:cell_membrane
gptkb:cytoplasm |
| gptkbp:mutationAssociatedWith |
developmental disorders
oncogenic potential |
| gptkbp:regulates |
insulin signaling
growth factor signaling immune cell signaling |
| gptkbp:species |
gptkb:Homo_sapiens
|
| gptkbp:UniProtID |
Q06124
|
| gptkbp:bfsParent |
gptkb:GAB1
gptkb:PTPN11 gptkb:PTPN11_gene gptkb:Gab2 |
| gptkbp:bfsLayer |
7
|