Prostaglandin-endoperoxide synthase 2

URI: https://gptkb.org/entity/Prostaglandin-endoperoxide_synthase_2
GPTKB entity
Statements (49)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkb:enzyme
gptkbp:alsoKnownAs gptkb:COX-2
gptkb:PTGS2
gptkbp:associatedWith gptkb:cancer
fever
pain
inflammation
gptkbp:biologicalProcess inflammatory response
prostaglandin biosynthetic process
prostaglandin-endoperoxide synthase activity
response to cytokine
gptkbp:catalyzes conversion of arachidonic acid to prostaglandin H2
gptkbp:discoveredIn 1991
gptkbp:domain cyclooxygenase domain
peroxidase domain
gptkbp:EC_number 1.14.99.1
gptkbp:encodedBy gptkb:PTGS2_gene
gptkbp:expressedIn macrophages
endothelial cells
epithelial cells
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:GOID GO:0004666
https://www.w3.org/2000/01/rdf-schema#label Prostaglandin-endoperoxide synthase 2
gptkbp:inducedBy cytokines
growth factors
inflammatory stimuli
gptkbp:inhibitedBy gptkb:ibuprofen
gptkb:naproxen
gptkb:NSAIDs
gptkb:rofecoxib
gptkb:aspirin
gptkb:celecoxib
gptkbp:length 604 amino acids
gptkbp:locatedOnChromosome chromosome 1q31.1
gptkbp:mass 69 kDa
gptkbp:OMIM 600262
gptkbp:orthologIn gptkb:Bos_taurus
gptkb:Gallus_gallus
gptkb:Mus_musculus
gptkb:Canis_lupus_familiaris
gptkb:Rattus_norvegicus
gptkbp:PDB 5F19
gptkbp:structure homodimer
gptkbp:subcellularLocation gptkb:endoplasmic_reticulum
nuclear envelope
gptkbp:UniProtID P35354
gptkbp:bfsParent gptkb:NM_002524
gptkbp:bfsLayer 7