|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:act_as
|
transcriptional activators
|
|
gptkbp:antagonize
|
gptkb:Polycomb_group_proteins
|
|
gptkbp:bind_to
|
chromatin
|
|
gptkbp:catalyzes
|
histone H3 lysine 4 methylation
|
|
gptkbp:conservedIn
|
gptkb:metazoans
|
|
gptkbp:contains
|
SET domain
|
|
gptkbp:discoveredBy
|
Drosophila genetic screens
|
|
gptkbp:firstDescribed
|
1980s
|
|
gptkbp:foundIn
|
gptkb:Homo_sapiens
gptkb:Drosophila_melanogaster
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Trithorax group proteins
|
|
gptkbp:include
|
gptkb:BRM
gptkb:CBP
gptkb:MLL2
gptkb:MLL4
gptkb:ASH1
gptkb:MLL1
gptkb:Trithorax_(Trx)
MLL3
|
|
gptkbp:interact_with
|
chromatin remodeling complexes
histone acetyltransferases
|
|
gptkbp:involves
|
epigenetic regulation
developmental gene regulation
|
|
gptkbp:maintainedBy
|
active chromatin state
|
|
gptkbp:mutationAssociatedWith
|
homeotic transformations
|
|
gptkbp:opposedBy
|
gptkb:Polycomb_group_proteins
|
|
gptkbp:regulates
|
gptkb:Hox_genes
gene expression
developmental patterning
|
|
gptkbp:requires
|
maintenance of cell identity
|
|
gptkbp:bfsParent
|
gptkb:PcG
gptkb:Polycomb_Repressive_Complex_1_(PRC1)
gptkb:Polycomb_Repressive_Complex_2
gptkb:Polycomb_group_proteins
gptkb:Polycomb_group
|
|
gptkbp:bfsLayer
|
8
|