|
gptkbp:instanceOf
|
gptkb:protein
gptkb:epigenetic_regulator
|
|
gptkbp:amendedBy
|
histone H2A lysine 119
histone H3 lysine 27
|
|
gptkbp:associatedWith
|
histone methylation
histone ubiquitination
|
|
gptkbp:binds
|
chromatin
|
|
gptkbp:component
|
gptkb:Polycomb_repressive_complex_1
gptkb:Polycomb_repressive_complex_2
|
|
gptkbp:discoveredIn
|
gptkb:Drosophila_melanogaster
|
|
gptkbp:enemyOf
|
gptkb:Trithorax_group_proteins
|
|
gptkbp:firstDescribed
|
1947
|
|
gptkbp:foundIn
|
animals
fungi
plants
|
|
gptkbp:function
|
gene silencing
chromatin modification
|
|
gptkbp:inhibitedBy
|
transcription
|
|
gptkbp:involvedIn
|
cancer progression
cell fate determination
stem cell maintenance
developmental regulation
|
|
gptkbp:involves
|
gptkb:X-chromosome_inactivation
embryonic development
cellular senescence
imprinting
neurogenesis
tumorigenesis
hematopoiesis
epigenetic memory
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:namedAfter
|
gptkb:Polycomb_gene
|
|
gptkbp:opposedBy
|
gptkb:Trithorax_group_proteins
|
|
gptkbp:proteinFamily
|
gptkb:PcG
|
|
gptkbp:regulates
|
gptkb:Hox_genes
|
|
gptkbp:studiedIn
|
cancer research
developmental biology
epigenetics
|
|
gptkbp:subunit
|
gptkb:EED
gptkb:EZH2
gptkb:RING1B
gptkb:SUZ12
BMI1
|
|
gptkbp:target
|
long non-coding RNAs
microRNAs
|
|
gptkbp:bfsParent
|
gptkb:EZH3
gptkb:GAGA
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Polycomb group proteins
|