|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
Polycomb group (PcG) complex 2
|
|
gptkbp:associatedWith
|
gptkb:cancer
developmental disorders
|
|
gptkbp:catalyzes
|
trimethylation of histone H3 at lysine 27 (H3K27me3)
|
|
gptkbp:component
|
gptkb:EED
gptkb:RBBP7
gptkb:EZH2
gptkb:EZH1
gptkb:PHF19
gptkb:AEBP2
gptkb:JARID2
gptkb:SUZ12
gptkb:RBBP4
|
|
gptkbp:discoveredIn
|
gptkb:Drosophila_melanogaster
|
|
gptkbp:firstDescribed
|
1998
|
|
gptkbp:form
|
chromatin-modifying complex
|
|
gptkbp:fullName
|
gptkb:Polycomb_Repressive_Complex_2
|
|
gptkbp:function
|
histone methyltransferase
|
|
gptkbp:geneEncodingComponent
|
gptkb:EZH2_gene
EED gene
EZH1 gene
SUZ12 gene
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PRC2
|
|
gptkbp:inhibitedBy
|
gptkb:EPZ-6438
gptkb:GSK126
gptkb:tazemetostat
|
|
gptkbp:interactsWith
|
gptkb:PRC1
long non-coding RNAs
|
|
gptkbp:involvedIn
|
gene silencing
epigenetic regulation
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Weaver_syndrome
various cancers
|
|
gptkbp:orthologIn
|
fungi
mammals
plants
|
|
gptkbp:regulates
|
gptkb:HOX_genes
gptkb:X-chromosome_inactivation
cell differentiation
cell proliferation
embryonic development
cell fate determination
stem cell pluripotency
|
|
gptkbp:requires
|
maintenance of repressive chromatin state
|
|
gptkbp:target
|
therapeutic inhibitors
oncogenic mutations
|
|
gptkbp:bfsParent
|
gptkb:Polycomb_repressive_complex_2
gptkb:Xist_RNA
gptkb:PcG
gptkb:Polycomb_Repressive_Complex_2
|
|
gptkbp:bfsLayer
|
8
|