Statements (67)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:associated_with |
gptkb:Oncology
|
| gptkbp:community |
chromatin structure
|
| gptkbp:composed_of |
gptkb:EZH2
SUZ12 EED |
| gptkbp:discovered_by |
gptkb:Drosophila_melanogaster
|
| gptkbp:function |
gene silencing
|
| gptkbp:has_role |
stem cell pluripotency
embryonic stem cell maintenance |
| https://www.w3.org/2000/01/rdf-schema#label |
PRC2
|
| gptkbp:initiated_by |
gene expression
|
| gptkbp:interacts_with |
H3 K27me3
|
| gptkbp:involved_in |
cell differentiation
developmental processes |
| gptkbp:is_associated_with |
metabolic disorders
autoimmune diseases chronic diseases chronic inflammation metastasis psychiatric disorders neurodevelopmental disorders |
| gptkbp:is_essential_for |
X-inactivation
|
| gptkbp:is_found_in |
gptkb:Atom
|
| gptkbp:is_involved_in |
DNA damage response
cell cycle regulation cellular homeostasis cellular metabolism cellular stress response chromatin remodeling immune response neuroplasticity cellular senescence tumorigenesis cellular aging tissue regeneration neurogenesis cellular signaling pathways cellular signaling vascular development epigenetic regulation neural differentiation cellular repair mechanisms stem cell differentiation reproductive development |
| gptkbp:is_linked_to |
aging
genetic disorders cardiovascular diseases infectious diseases developmental disorders epigenetic memory |
| gptkbp:is_part_of |
Polycomb group proteins
Polycomb repressive complex |
| gptkbp:is_regulated_by |
environmental factors
transcription factors hormones signaling pathways nutritional factors non-coding RNAs |
| gptkbp:is_studied_for |
therapeutic interventions
|
| gptkbp:is_studied_in |
cancer research
|
| gptkbp:is_targeted_at |
small molecules
epigenetic drugs |
| gptkbp:regulates |
transcriptional repression
histone methylation |
| gptkbp:bfsParent |
gptkb:ASXL1
|
| gptkbp:bfsLayer |
6
|