|
gptkbp:instanceOf
|
gptkb:protein
epigenetic regulator
|
|
gptkbp:amendedBy
|
histone H2A lysine 119
histone H3 lysine 27
|
|
gptkbp:associatedWith
|
histone methylation
histone ubiquitination
|
|
gptkbp:binds
|
chromatin
|
|
gptkbp:component
|
gptkb:Polycomb_Repressive_Complex_1
gptkb:Polycomb_Repressive_Complex_2
|
|
gptkbp:discoveredIn
|
gptkb:Drosophila_melanogaster
|
|
gptkbp:enemyOf
|
gptkb:Trithorax-group_proteins
|
|
gptkbp:firstDescribed
|
1947
|
|
gptkbp:foundIn
|
eukaryotes
|
|
gptkbp:function
|
gene silencing
chromatin modification
|
|
gptkbp:gene
|
gptkb:PcG
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Polycomb-group proteins
|
|
gptkbp:involvedIn
|
cancer progression
cell identity maintenance
developmental regulation
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:mechanismOfAction
|
histone modification
chromatin compaction
recruitment of other repressors
|
|
gptkbp:mutationAssociatedWith
|
developmental defects
homeotic transformations
|
|
gptkbp:namedAfter
|
gptkb:Polycomb_gene
|
|
gptkbp:orthologIn
|
animals
fungi
plants
|
|
gptkbp:regulates
|
gptkb:Hox_genes
|
|
gptkbp:relatedTo
|
gptkb:X-chromosome_inactivation
embryonic development
epigenetic inheritance
tumorigenesis
transcriptional repression
stem cell pluripotency
|
|
gptkbp:subunit
|
gptkb:EED
gptkb:EZH2
gptkb:CBX_proteins
gptkb:PHC_proteins
gptkb:RING1A
gptkb:RING1B
gptkb:SUZ12
BMI1
|
|
gptkbp:target
|
transcription factors
long non-coding RNAs
microRNAs
|
|
gptkbp:bfsParent
|
gptkb:Ezh3
|
|
gptkbp:bfsLayer
|
6
|