Statements (29)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:abbreviation |
gptkb:PDE4
|
| gptkbp:biologicalProcess |
signal transduction
|
| gptkbp:EC_number |
3.1.4.53
|
| gptkbp:expressedIn |
gptkb:cancer
brain immune cells inflammatory cells |
| gptkbp:function |
hydrolyzes cAMP
|
| https://www.w3.org/2000/01/rdf-schema#label |
phosphodiesterase type 4
|
| gptkbp:inhibitedBy |
gptkb:rolipram
gptkb:roflumilast apremilast cilomilast |
| gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
| gptkbp:medicalUse |
target for anti-inflammatory drugs
target for COPD treatment target for psoriasis treatment |
| gptkbp:product |
gptkb:AMP
|
| gptkbp:proteinFamily |
PDE4A
PDE4B PDE4C PDE4D |
| gptkbp:regulates |
regulated by phosphorylation
regulated by protein-protein interactions |
| gptkbp:substrate |
cyclic AMP
|
| gptkbp:bfsParent |
gptkb:Phosphodiesterase
|
| gptkbp:bfsLayer |
7
|