Statements (32)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:abbreviation |
gptkb:PDE5
|
| gptkbp:biologicalProcess |
phosphodiesterase activity
|
| gptkbp:cofactor |
Mg2+
Zn2+ |
| gptkbp:discoveredBy |
1990s
|
| gptkbp:EC_number |
3.1.4.17
|
| gptkbp:foundIn |
gptkb:human
mammals |
| gptkbp:function |
hydrolyzes cGMP
|
| gptkbp:gene |
PDE5A
|
| https://www.w3.org/2000/01/rdf-schema#label |
phosphodiesterase type 5
|
| gptkbp:inhibitedBy |
gptkb:vardenafil
gptkb:avanafil gptkb:sildenafil gptkb:tadalafil increases cGMP levels induces smooth muscle relaxation |
| gptkbp:location |
smooth muscle
corpus cavernosum pulmonary vasculature |
| gptkbp:medicalUse |
target for erectile dysfunction drugs
target for pulmonary hypertension drugs |
| gptkbp:product |
gptkb:GMP
|
| gptkbp:regulates |
regulated by nitric oxide pathway
|
| gptkbp:role |
erectile dysfunction
pulmonary arterial hypertension |
| gptkbp:structure |
homodimer
|
| gptkbp:substrate |
gptkb:cGMP
|
| gptkbp:bfsParent |
gptkb:PDE5
gptkb:Phosphodiesterase |
| gptkbp:bfsLayer |
7
|