|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alsoKnownAs
|
gptkb:PTPN6
gptkb:SHP-1
|
|
gptkbp:domain
|
gptkb:protein_tyrosine_phosphatase_domain
SH2 domain
|
|
gptkbp:encodedBy
|
PTPN6 gene
|
|
gptkbp:Entrez_Gene_ID
|
5777
|
|
gptkbp:expressedIn
|
hematopoietic cells
|
|
gptkbp:function
|
protein tyrosine phosphatase activity
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PTP1C
|
|
gptkbp:interactsWith
|
gptkb:JAK2
gptkb:CD22
gptkb:Syk
gptkb:Lyn
gptkb:CD72
gptkb:STAT5
|
|
gptkbp:involvedIn
|
signal transduction
negative regulation of cell signaling
|
|
gptkbp:locale
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:locatedOnChromosome
|
12q24.13
|
|
gptkbp:molecularWeight
|
68 kDa
|
|
gptkbp:mutationAssociatedWith
|
leukemia
autoimmune diseases
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInMouse
|
gptkb:Ptpn6
|
|
gptkbp:PDB
|
1GMX
|
|
gptkbp:RefSeq
|
NP_002822.2
|
|
gptkbp:regulates
|
gptkb:MAPK_signaling_pathway
gptkb:JAK/STAT_signaling_pathway
apoptosis
cell differentiation
cell proliferation
cell migration
cell cycle
allergic response
phagocytosis
cell adhesion
inflammatory response
insulin signaling
macrophage activation
hematopoiesis
B cell receptor signaling
growth factor signaling
immune cell signaling
cytokine signaling
mast cell activation
T cell receptor signaling
|
|
gptkbp:UniProtID
|
gptkb:P29350
|
|
gptkbp:bfsParent
|
gptkb:PTPN2
|
|
gptkbp:bfsLayer
|
7
|