Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:gene
|
| gptkbp:alias |
BLIMP1
PRDI-BF1 |
| gptkbp:associatedWith |
diffuse large B-cell lymphoma
immunodeficiency |
| gptkbp:biologicalProcess |
DNA binding
plasma cell differentiation negative regulation of transcription |
| gptkbp:discoveredBy |
Keller and Maniatis
|
| gptkbp:encodes |
gptkb:PR_domain_zinc_finger_protein_1
|
| gptkbp:Entrez_Gene_ID |
gptkb:ENSG00000119715
639 |
| gptkbp:expressedIn |
gptkb:B_cells
gptkb:T_cells |
| gptkbp:firstDescribed |
1996
|
| gptkbp:function |
regulation of immune response
transcriptional repressor regulation of B cell differentiation |
| gptkbp:geneType |
protein-coding
|
| gptkbp:HGNC_ID |
9346
|
| https://www.w3.org/2000/01/rdf-schema#label |
PRDM1 gene
|
| gptkbp:involvedIn |
chromatin modification
epigenetic regulation |
| gptkbp:length |
7 exons
|
| gptkbp:locatedOnChromosome |
gptkb:chromosome_6
gptkb:6q21 |
| gptkbp:mutationAssociatedWith |
germline mutation in immunodeficiency
loss of function associated with lymphoma somatic mutation in cancer |
| gptkbp:OMIM |
603423
|
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:orthologInMouse |
gptkb:Prdm1
|
| gptkbp:proteinFamily |
gptkb:PRDM_family
zinc finger domain PR domain |
| gptkbp:RefSeq |
NM_001198
|
| gptkbp:regulates |
yes
gene silencing cell cycle arrest germinal center reaction T cell homeostasis apoptosis in immune cells immune cell fate interferon-beta gene expression terminal differentiation of B lymphocytes |
| gptkbp:target |
microRNAs
|
| gptkbp:UniProtID |
gptkb:O75626
|
| gptkbp:bfsParent |
gptkb:chromosome_6_(human)
|
| gptkbp:bfsLayer |
7
|