Statements (64)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:gene_therapy
gptkb:CRISPR_technology gptkb:secondary_acute_myeloid_leukemia RNA interference DNA damage response biomarker discovery cell cycle regulation cell differentiation chromatin remodeling clinical trials data sharing genetic testing biological samples collaborative research targeted therapies tumor microenvironment clinical outcomes longitudinal studies precision medicine metastasis therapeutic targets stem cell maintenance therapeutic resistance molecular profiling patient stratification immune evasion increased risk of transformation poor prognosis in cancer prognostic markers age-related mutations clonal hematopoiesis dysregulated hematopoiesis epigenetic alterations myeloid malignancies |
| gptkbp:clinical_trial |
biomarker for therapy response
|
| gptkbp:diseases |
gptkb:myelodysplastic_syndromes
gptkb:Oncology gptkb:chronic_myelomonocytic_leukemia solid tumors lymphoid malignancies |
| gptkbp:function |
regulation of gene expression
|
| gptkbp:genetic_studies |
loss of function
somatic mutation |
| https://www.w3.org/2000/01/rdf-schema#label |
ASXL1
|
| gptkbp:interacts_with |
gptkb:EZH2
gptkb:PRC2 |
| gptkbp:is_expressed_in |
hematopoietic cells
|
| gptkbp:located_in |
human chromosome 20
|
| gptkbp:nutritional_value |
gptkb:ASXL1_protein
|
| gptkbp:orthologs |
ASXL1 in other species
|
| gptkbp:pathway |
Wnt signaling pathway
Notch signaling pathway TGF-beta signaling pathway |
| gptkbp:research_focus |
cancer genomics
|
| gptkbp:role |
epigenetic regulation
|
| gptkbp:seed_dispersal |
protein-coding gene
|
| gptkbp:variant |
gptkb:ASXL1_E1017_K
gptkb:ASXL1_K1006_R gptkb:ASXL1_P703_L gptkb:ASXL1_Q646_X gptkb:ASXL1_R726_X |
| gptkbp:bfsParent |
gptkb:myelodysplastic_syndromes
|
| gptkbp:bfsLayer |
5
|