|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:arrangedFor
|
clusters
|
|
gptkbp:clusterNamesInHumans
|
gptkb:HOXA
gptkb:HOXB
gptkb:HOXC
gptkb:HOXD
|
|
gptkbp:contains
|
homeobox domain
|
|
gptkbp:discoveredIn
|
gptkb:Drosophila_melanogaster
|
|
gptkbp:dysregulationAssociatedWith
|
gptkb:cancer
leukemia
congenital malformations
|
|
gptkbp:encodes
|
transcription factors
|
|
gptkbp:evolutionaryConservation
|
high
|
|
gptkbp:expressedIn
|
embryogenesis
|
|
gptkbp:firstDescribed
|
gptkb:Edward_B._Lewis
|
|
gptkbp:foundIn
|
animals
|
|
gptkbp:function
|
body plan specification
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
HOX genes
|
|
gptkbp:locatedOnHumanChromosomes
|
gptkb:chromosome_7
gptkb:chromosome_17
gptkb:chromosome_12
chromosome 2
|
|
gptkbp:mutationAssociatedWith
|
developmental disorders
|
|
gptkbp:NobelPrizeRelatedTo
|
gptkb:1995_Nobel_Prize_in_Physiology_or_Medicine
|
|
gptkbp:numberOfClustersInHumans
|
4
|
|
gptkbp:numberOfGenes
|
39
|
|
gptkbp:orthologIn
|
gptkb:meat
gptkb:zebrafish
gptkb:amphioxus
humans
frogs
mice
worms
sea urchins
flies
homeotic genes
cnidarians
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
cell proliferation
embryonic development
organogenesis
neural development
urogenital system development
limb development
gastrointestinal tract development
skeletal patterning
anterior-posterior axis
reproductive tract development
|
|
gptkbp:relatedTo
|
segment identity
|
|
gptkbp:studiedBy
|
gptkb:CRISPR/Cas9
gptkb:RNA_interference
gene knockout
RNA sequencing
in situ hybridization
chromatin immunoprecipitation
transgenic animals
reporter assays
|
|
gptkbp:studiedIn
|
invertebrates
vertebrates
|
|
gptkbp:bfsParent
|
gptkb:Retinoic_acid_receptor
gptkb:HOX_proteins
|
|
gptkbp:bfsLayer
|
7
|