|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:diabetes
cancer metabolism
metabolic regulation
|
|
gptkbp:biologicalProcess
|
kinase activity
regulation of glucose metabolism
negative regulation of pyruvate dehydrogenase activity
|
|
gptkbp:cellularComponent
|
mitochondrion
|
|
gptkbp:encodes
|
gptkb:pyruvate_dehydrogenase_kinase_isoform_2
|
|
gptkbp:Entrez_Gene_ID
|
5164
ENSG00000152256
|
|
gptkbp:expressedIn
|
gptkb:skeletal_muscle
gptkb:kidney
heart
liver
pancreas
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
gptkb:Rattus_norvegicus
|
|
gptkbp:fullName
|
gptkb:pyruvate_dehydrogenase_kinase_isoform_2
|
|
gptkbp:gene
|
gptkb:PDK2
|
|
gptkbp:hasBiologicalActivity
|
EC 2.7.11.2
|
|
gptkbp:hasTranscriptVariant
|
NM_002612.4
|
|
gptkbp:HGNC_ID
|
HGNC:8807
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
PDK2
|
|
gptkbp:inhibitedBy
|
gptkb:AZD7545
gptkb:dichloroacetate
gptkb:pyruvate_dehydrogenase_(PDH)
|
|
gptkbp:length
|
407 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:17q21.33
|
|
gptkbp:molecularWeight
|
46 kDa
|
|
gptkbp:OMIM
|
602524
|
|
gptkbp:orthologInMouse
|
gptkb:Pdk2
|
|
gptkbp:PDB
|
2BU8
2E4F
|
|
gptkbp:phosphorylates
|
gptkb:E1_component_of_PDH_complex
|
|
gptkbp:regulates
|
gptkb:insulin
gptkb:pyruvate_dehydrogenase_complex
gptkb:hypoxia
gptkb:HIF-1alpha
gptkb:glucocorticoids
gptkb:peroxisome_proliferator-activated_receptor_(PPAR)
starvation
hormone
fatty acids
|
|
gptkbp:significance
|
gptkb:cancer
gptkb:type_2_diabetes
gptkb:metabolic_syndrome
|
|
gptkbp:UniProtID
|
Q15118
|
|
gptkbp:bfsParent
|
gptkb:PDK1
|
|
gptkbp:bfsLayer
|
6
|