Statements (31)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
|
| gptkbp:activatesTranscriptionOf |
gptkb:LDHA
gptkb:EPO gptkb:GLUT1 gptkb:VEGF genes involved in angiogenesis genes involved in glycolysis |
| gptkbp:associatedWith |
gptkb:cancer
inflammation ischemia |
| gptkbp:degradedBy |
gptkb:proteasome
gptkb:VHL_protein oxygen levels |
| gptkbp:discoveredBy |
gptkb:Gregg_L._Semenza
|
| gptkbp:encodedBy |
gptkb:HIF1A_gene
|
| gptkbp:formsComplexWith |
HIF-1beta
|
| gptkbp:fullName |
gptkb:Hypoxia-inducible_factor_1-alpha
|
| gptkbp:function |
gptkb:transcription_factor
regulates response to hypoxia |
| gptkbp:locale |
gptkb:nucleus
|
| gptkbp:locatedOnChromosome |
14q23.2
|
| gptkbp:organism |
gptkb:human
|
| gptkbp:postTranslationalModification |
ubiquitination
hydroxylation |
| gptkbp:structure |
transactivation domain
PAS domain basic helix-loop-helix domain |
| gptkbp:UniProtID |
Q16665
|
| gptkbp:bfsParent |
gptkb:PDK2
|
| gptkbp:bfsLayer |
7
|
| http://www.w3.org/2000/01/rdf-schema#label |
HIF-1alpha
|