pyruvate dehydrogenase complex
GPTKB entity
Statements (36)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:enzyme
|
| gptkbp:activatedBy |
gptkb:pyruvate
gptkb:ADP Ca2+ |
| gptkbp:catalyzes |
conversion of pyruvate to acetyl-CoA
|
| gptkbp:cofactor |
gptkb:Coenzyme_A
gptkb:FAD NAD+ thiamine pyrophosphate lipoic acid |
| gptkbp:composedOf |
gptkb:E1_(pyruvate_dehydrogenase)
gptkb:E2_(dihydrolipoamide_acetyltransferase) gptkb:E3_(dihydrolipoamide_dehydrogenase) |
| gptkbp:deficiencyCauses |
lactic acidosis
|
| gptkbp:EC_number |
1.2.4.1
1.8.1.4 2.3.1.12 |
| gptkbp:foundIn |
mitochondria
|
| gptkbp:gene |
gptkb:DLD
gptkb:DLAT gptkb:PDHB gptkb:PDHX gptkb:PDHA1 |
| https://www.w3.org/2000/01/rdf-schema#label |
pyruvate dehydrogenase complex
|
| gptkbp:inhibitedBy |
gptkb:NADH
acetyl-CoA |
| gptkbp:molecularWeight |
~9 MDa
|
| gptkbp:partOf |
aerobic respiration
|
| gptkbp:presentIn |
eukaryotes
some prokaryotes |
| gptkbp:regulates |
phosphorylation
dephosphorylation |
| gptkbp:bfsParent |
gptkb:Mitochondrion
gptkb:pyruvate gptkb:pyruvate_dehydrogenase |
| gptkbp:bfsLayer |
6
|