|
gptkbp:instanceOf
|
analgesic
Antiplatelet drug
Antipyretic
nonsteroidal anti-inflammatory drug
|
|
gptkbp:ATCCode
|
B01AC06
|
|
gptkbp:brand
|
gptkb:Bayer
gptkb:St._Joseph
gptkb:Bufferin
gptkb:Ecotrin
|
|
gptkbp:CASNumber
|
50-78-2
|
|
gptkbp:category
|
Over-the-counter drug
Essential medicine
|
|
gptkbp:chemicalFormula
|
C9H8O4
|
|
gptkbp:contraindication
|
Aspirin allergy
Children with viral infections
Hemophilia
Peptic ulcer disease
|
|
gptkbp:developedBy
|
gptkb:Bayer
|
|
gptkbp:discoveredBy
|
gptkb:Felix_Hoffmann
|
|
gptkbp:discoveredIn
|
1897
|
|
gptkbp:eliminationHalfLife
|
15–30 hours (high dose)
2–3 hours (low dose)
|
|
gptkbp:excretion
|
Kidney
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Aspirin
|
|
gptkbp:IUPACName
|
2-acetoxybenzoic acid
|
|
gptkbp:legalStatus
|
OTC (over-the-counter)
|
|
gptkbp:marketedAs
|
1899
|
|
gptkbp:mechanismOfAction
|
Inhibits cyclooxygenase (COX-1 and COX-2)
Irreversibly inhibits platelet aggregation
Reduces prostaglandin synthesis
|
|
gptkbp:meltingPoint
|
135°C
|
|
gptkbp:metabolism
|
Liver
|
|
gptkbp:molecularWeight
|
180.16 g/mol
|
|
gptkbp:patentExpired
|
1917
|
|
gptkbp:pregnancyCategory
|
D (US)
|
|
gptkbp:riskFactor
|
gptkb:Reye's_syndrome_in_children
|
|
gptkbp:routeOfAdministration
|
gptkb:Oral
Rectal
|
|
gptkbp:sideEffect
|
Allergic reaction
Gastrointestinal bleeding
Stomach ulcer
|
|
gptkbp:solubility
|
3 g/L (20°C)
|
|
gptkbp:synonym
|
gptkb:ASA
gptkb:Acetylsalicylic_acid
|
|
gptkbp:usedFor
|
Fever reduction
Inflammation reduction
Pain relief
Prevention of blood clots
|
|
gptkbp:WHOModelListOfEssentialMedicines
|
Yes
|
|
gptkbp:bfsParent
|
gptkb:Bayer
|
|
gptkbp:bfsLayer
|
5
|