|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:CERP
gptkb:TGD
HDLCQTL13
|
|
gptkbp:associatedWith
|
gptkb:Tangier_disease
gptkb:familial_high-density_lipoprotein_deficiency
|
|
gptkbp:biologicalProcess
|
reverse cholesterol transport
ATPase activity
transmembrane transporter activity
cholesterol metabolic process
lipid homeostasis
|
|
gptkbp:cellularComponent
|
gptkb:cell_membrane
gptkb:plasma_membrane
|
|
gptkbp:discoveredBy
|
gptkb:Michael_Hayden
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000165029
19
|
|
gptkbp:expressedIn
|
gptkb:cancer
liver
adipose tissue
macrophages
intestine
|
|
gptkbp:fullName
|
gptkb:ATP-binding_cassette_sub-family_A_member_1
|
|
gptkbp:function
|
lipid transport
cholesterol efflux
phospholipid efflux
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:GOID
|
GO:0033344
|
|
gptkbp:HGNC_ID
|
gptkb:HGNC:29
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ABCA1
|
|
gptkbp:length
|
2261 amino acids
|
|
gptkbp:locatedOnChromosome
|
gptkb:9q31.1
9
|
|
gptkbp:molecularWeight
|
254 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Tangier_disease_phenotype
low HDL cholesterol
|
|
gptkbp:OMIM
|
600046
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
gptkb:mouse_Abca1
gptkb:rat_Abca1
|
|
gptkbp:PDB
|
7R8D
7R8E
7R8F
7R8G
7R8H
7R8I
|
|
gptkbp:proteinFamily
|
gptkb:ATP-binding_cassette_transporter_family
|
|
gptkbp:regulates
|
HDL formation
apoA-I binding
|
|
gptkbp:subfamily
|
gptkb:ABCA_subfamily
|
|
gptkbp:UniProtID
|
gptkb:O95477
|
|
gptkbp:vehicleType
|
ABC transporter
|
|
gptkbp:bfsParent
|
gptkb:LXR
|
|
gptkbp:bfsLayer
|
6
|