|
gptkbp:instanceOf
|
gptkb:protein
gptkb:gene
|
|
gptkbp:alias
|
gptkb:ApoA-I
gptkb:ApoA1
gptkb:Apolipoprotein_A1
|
|
gptkbp:alternativeSplicing
|
no
|
|
gptkbp:associatedWith
|
high-density lipoprotein
|
|
gptkbp:clinicalTrialPhase
|
HDL cholesterol measurement
|
|
gptkbp:component
|
gptkb:HDL_particle
|
|
gptkbp:discoveredBy
|
gptkb:Donald_Fredrickson
|
|
gptkbp:encodes
|
gptkb:apolipoprotein_A-I
|
|
gptkbp:Entrez_Gene_ID
|
335
ENSG00000118137
|
|
gptkbp:expressedIn
|
gptkb:small_intestine
liver
|
|
gptkbp:firstDescribed
|
1975
|
|
gptkbp:function
|
reverse cholesterol transport
cholesterol transport
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
HGNC:600
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
APOA1
|
|
gptkbp:interactsWith
|
gptkb:LCAT
gptkb:ABCA1
|
|
gptkbp:length
|
267
|
|
gptkbp:locatedOnChromosome
|
chromosome 11
11q23-q24
|
|
gptkbp:molecularWeight
|
28 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Tangier_disease
gptkb:familial_HDL_deficiency
increased risk of cardiovascular disease
low HDL cholesterol
|
|
gptkbp:OMIM
|
107680
|
|
gptkbp:orthologInMouse
|
gptkb:Apoa1
|
|
gptkbp:pathway
|
lipid metabolism
reverse cholesterol transport
cholesterol efflux
|
|
gptkbp:postTranslationalModification
|
phosphorylation
oxidation
glycosylation
|
|
gptkbp:product
|
gptkb:apolipoprotein_A-I
amphipathic alpha-helix
|
|
gptkbp:subcellularLocation
|
gptkb:plasma
extracellular
|
|
gptkbp:target
|
gptkb:fibrates
niacin
statins
|
|
gptkbp:UniProtID
|
P02647
|
|
gptkbp:bfsParent
|
gptkb:A0G
|
|
gptkbp:bfsLayer
|
6
|