|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:abbreviation
|
gptkb:Hsp90
|
|
gptkbp:category
|
gptkb:heat_shock_protein
gptkb:molecular_chaperone
stress protein
|
|
gptkbp:conservedIn
|
prokaryotes
eukaryotes
|
|
gptkbp:discoveredBy
|
gptkb:Ferruccio_Ritossa
|
|
gptkbp:discoveredIn
|
1962
|
|
gptkbp:foundIn
|
gptkb:Bacteria
eukaryotes
|
|
gptkbp:function
|
gptkb:molecular_chaperone
protein folding
prevention of protein aggregation
stabilization of proteins
|
|
gptkbp:gene
|
gptkb:HSP90AA1
gptkb:HSP90AB1
gptkb:HSP90B1
gptkb:TRAP1
|
|
gptkbp:inducedBy
|
heat shock
cellular stress
|
|
gptkbp:inhibitedBy
|
gptkb:17-AAG
gptkb:geldanamycin
gptkb:radicicol
|
|
gptkbp:interactsWith
|
gptkb:steroid_hormone_receptors
gptkb:kinases
transcription factors
|
|
gptkbp:locale
|
gptkb:endoplasmic_reticulum
gptkb:cytoplasm
mitochondria
|
|
gptkbp:molecularWeight
|
~90 kDa
|
|
gptkbp:OMIM
|
140571
|
|
gptkbp:requires
|
protein homeostasis
cell viability
|
|
gptkbp:role
|
gptkb:cancer
signal transduction
neurodegenerative diseases
protein degradation
cell cycle control
|
|
gptkbp:structure
|
homodimer
C-terminal domain
ATPase domain
middle domain
|
|
gptkbp:target
|
anticancer drugs
|
|
gptkbp:UniProtID
|
gptkb:P07900
gptkb:P08238
|
|
gptkbp:bfsParent
|
gptkb:HSP90
|
|
gptkbp:bfsLayer
|
7
|
|
http://www.w3.org/2000/01/rdf-schema#label
|
Heat Shock Protein 90
|