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gptkbp:instanceOf
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gptkb:protein
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gptkbp:abbreviation
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gptkb:Hsp90
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gptkbp:category
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gptkb:heat_shock_protein
gptkb:molecular_chaperone
stress protein
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gptkbp:conservedIn
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prokaryotes
eukaryotes
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gptkbp:discoveredBy
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gptkb:Ferruccio_Ritossa
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gptkbp:discoveredIn
|
1962
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gptkbp:foundIn
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gptkb:Bacteria
eukaryotes
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gptkbp:function
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gptkb:molecular_chaperone
protein folding
prevention of protein aggregation
stabilization of proteins
|
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gptkbp:gene
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gptkb:HSP90AA1
gptkb:HSP90AB1
gptkb:HSP90B1
gptkb:TRAP1
|
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gptkbp:inducedBy
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heat shock
cellular stress
|
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gptkbp:inhibitedBy
|
gptkb:17-AAG
gptkb:geldanamycin
gptkb:radicicol
|
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gptkbp:interactsWith
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gptkb:steroid_hormone_receptors
gptkb:kinases
transcription factors
|
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gptkbp:locale
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gptkb:endoplasmic_reticulum
gptkb:cytoplasm
mitochondria
|
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gptkbp:molecularWeight
|
~90 kDa
|
|
gptkbp:OMIM
|
140571
|
|
gptkbp:requires
|
protein homeostasis
cell viability
|
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gptkbp:role
|
gptkb:cancer
signal transduction
neurodegenerative diseases
protein degradation
cell cycle control
|
|
gptkbp:structure
|
homodimer
C-terminal domain
ATPase domain
middle domain
|
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gptkbp:target
|
anticancer drugs
|
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gptkbp:UniProtID
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gptkb:P07900
gptkb:P08238
|
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gptkbp:bfsParent
|
gptkb:HSP90
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gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Heat Shock Protein 90
|