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gptkbp:instanceOf
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gptkb:protein
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gptkbp:abbreviation
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gptkb:Hsp90
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gptkbp:category
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molecular chaperone
stress protein
heat shock protein
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gptkbp:conservedIn
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prokaryotes
eukaryotes
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gptkbp:discoveredBy
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gptkb:Ferruccio_Ritossa
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gptkbp:discoveredIn
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1962
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gptkbp:foundIn
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gptkb:Bacteria
eukaryotes
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gptkbp:function
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protein folding
molecular chaperone
prevention of protein aggregation
stabilization of proteins
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gptkbp:gene
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gptkb:HSP90AA1
gptkb:HSP90AB1
gptkb:HSP90B1
gptkb:TRAP1
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https://www.w3.org/2000/01/rdf-schema#label
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Heat Shock Protein 90
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gptkbp:inducedBy
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heat shock
cellular stress
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gptkbp:inhibitedBy
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gptkb:17-AAG
gptkb:geldanamycin
gptkb:radicicol
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gptkbp:interactsWith
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gptkb:steroid_hormone_receptors
gptkb:kinases
transcription factors
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gptkbp:locale
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gptkb:endoplasmic_reticulum
gptkb:cytoplasm
mitochondria
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gptkbp:molecularWeight
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~90 kDa
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gptkbp:OMIM
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140571
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gptkbp:requires
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protein homeostasis
cell viability
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gptkbp:role
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gptkb:cancer
signal transduction
neurodegenerative diseases
protein degradation
cell cycle control
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gptkbp:structure
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homodimer
C-terminal domain
ATPase domain
middle domain
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gptkbp:target
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anticancer drugs
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gptkbp:UniProtID
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gptkb:P07900
gptkb:P08238
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gptkbp:bfsParent
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gptkb:HSP90
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gptkbp:bfsLayer
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7
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