|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:ApoA-I
Apolipoprotein AI
|
|
gptkbp:associatedWith
|
gptkb:Tangier_disease
gptkb:cardiovascular_disease
gptkb:amyloidosis
|
|
gptkbp:component
|
high-density lipoprotein
|
|
gptkbp:encodedBy
|
gptkb:APOA1_gene
|
|
gptkbp:Entrez_Gene_ID
|
335
ENSG00000118137
|
|
gptkbp:expressedIn
|
gptkb:small_intestine
liver
|
|
gptkbp:foundIn
|
gptkb:human
other mammals
|
|
gptkbp:fullName
|
gptkb:Apolipoprotein_A-I
|
|
gptkbp:function
|
cholesterol transport
activates LCAT
|
|
gptkbp:halfLife
|
4-5 days
|
|
gptkbp:HGNC_ID
|
600
|
|
gptkbp:interactsWith
|
gptkb:LCAT
gptkb:ABCA1
|
|
gptkbp:isotype
|
major protein component of HDL
|
|
gptkbp:locatedOnChromosome
|
chromosome 11
|
|
gptkbp:molecularWeight
|
28 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:amyloidosis
increased risk of atherosclerosis
HDL deficiency
|
|
gptkbp:OMIM
|
107680
|
|
gptkbp:PDB
|
2A01
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:RefSeq
|
NM_000039
|
|
gptkbp:role
|
reverse cholesterol transport
|
|
gptkbp:sequence
|
243 amino acids
|
|
gptkbp:significance
|
associated with Tangier disease
associated with familial amyloidosis
mutations cause HDL deficiency
|
|
gptkbp:structure
|
amphipathic alpha-helix
|
|
gptkbp:subcellularLocation
|
gptkb:HDL_particle
gptkb:plasma
extracellular
|
|
gptkbp:UniProtID
|
P02647
|
|
gptkbp:usedAs
|
biomarker for cardiovascular disease
|
|
gptkbp:bfsParent
|
gptkb:APOA1
|
|
gptkbp:bfsLayer
|
7
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
ApoA1
|