Nuclear Receptor (biochemistry)

GPTKB entity

Predicate	Object
gptkbp:instanceOf	Transcription factor Protein family
gptkbp:alternativeName	Intracellular receptor Nuclear hormone receptor
gptkbp:binds	gptkb:Retinoic_acid Vitamin D Hormones Response elements on DNA Steroid hormones Thyroid hormones
gptkbp:compatibleWith	gptkb:Bacteria Archaea
gptkbp:contains	DNA-binding domain Ligand-binding domain
gptkbp:discoveredBy	1960s
gptkbp:domain	AF-1 domain AF-2 domain Hinge region
gptkbp:encodedBy	NR genes
gptkbp:example	gptkb:Androgen_receptor gptkb:Estrogen_receptor gptkb:Glucocorticoid_receptor gptkb:Peroxisome_proliferator-activated_receptor gptkb:Progesterone_receptor gptkb:Retinoic_acid_receptor gptkb:Thyroid_hormone_receptor
gptkbp:foundIn	gptkb:Fungi gptkb:Plants Animals
gptkbp:function	Regulation of gene expression
https://www.w3.org/2000/01/rdf-schema#label	Nuclear Receptor (biochemistry)
gptkbp:involves	gptkb:cancer gptkb:Metabolic_syndrome Diabetes Endocrine disorders
gptkbp:location	Cell nucleus
gptkbp:mechanismOfAction	Ligand-activated transcription
gptkbp:modulatedBy	Coactivators Corepressors
gptkbp:regulates	Development Metabolism Homeostasis
gptkbp:reviewedBy	gptkb:Annual_Review_of_Biochemistry gptkb:Nature_Reviews_Molecular_Cell_Biology
gptkbp:structure	Modular
gptkbp:superfamily	gptkb:Nuclear_receptor_superfamily
gptkbp:target	Pharmaceutical drugs
gptkbp:bfsParent	gptkb:NR
gptkbp:bfsLayer	5