Statements (49)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:chemical_compound
vitamin A derivative |
| gptkbp:actsOn |
signaling molecule
|
| gptkbp:administeredBy |
oral medication
topical medication |
| gptkbp:affects |
gptkb:DVD
cell differentiation embryonic development immune function |
| gptkbp:ATCCode |
D10AD02
|
| gptkbp:binds |
retinoid X receptor
retinoic acid receptor |
| gptkbp:CASNumber |
302-79-4
|
| gptkbp:category |
terpenoids
retinoids carboxylic acids |
| gptkbp:chemicalFormula |
C20H28O2
|
| gptkbp:derivedFrom |
gptkb:vitamin_A
|
| gptkbp:discoveredBy |
20th century
|
| gptkbp:foundIn |
animals
humans |
| gptkbp:has_tautomer |
retinoate
|
| https://www.w3.org/2000/01/rdf-schema#label |
Retinoic acid
|
| gptkbp:isomerOf |
gptkb:9-cis-retinoic_acid
13-cis-retinoic acid all-trans-retinoic acid |
| gptkbp:IUPACName |
(all-trans)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
|
| gptkbp:meltingPoint |
137–138 °C
|
| gptkbp:MeSH_ID |
gptkb:D011470
|
| gptkbp:metabolism |
CYP26 enzymes
|
| gptkbp:molecularWeight |
300.44 g/mol
|
| gptkbp:produces |
retinol oxidation
|
| gptkbp:PubChem_CID |
444795
CHEBI:26536 |
| gptkbp:regulates |
gene expression
|
| gptkbp:relatedTo |
gptkb:retinol
gptkb:isotretinoin retinal |
| gptkbp:sideEffect |
skin irritation
photosensitivity teratogenicity dry skin |
| gptkbp:solubility |
insoluble in water
soluble in organic solvents |
| gptkbp:UNII |
G2SH0X191U
|
| gptkbp:usedFor |
acne treatment
acute promyelocytic leukemia treatment |
| gptkbp:bfsParent |
gptkb:Nuclear_Receptor_(biochemistry)
|
| gptkbp:bfsLayer |
6
|