Statements (71)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:protein
|
| gptkbp:application |
Kinases
|
| gptkbp:associated_with |
Hypothyroidism
Hyperthyroidism |
| gptkbp:community |
Cell growth
|
| gptkbp:function |
Regulates gene expression
|
| gptkbp:has_variants |
THRA1
THRB1 |
| https://www.w3.org/2000/01/rdf-schema#label |
Thyroid hormone receptor
|
| gptkbp:influences |
Metabolic rate
|
| gptkbp:initiated_by |
gptkb:T3
Thyroid hormone antagonists |
| gptkbp:interacts_with |
Retinoid X receptor
|
| gptkbp:involved_in |
Metabolism
|
| gptkbp:is_dephosphorylated_by |
Phosphatases
|
| gptkbp:is_expressed_in |
gptkb:disease
gptkb:Brain gptkb:Heart Muscle Liver |
| gptkbp:is_involved_in |
Apoptosis
Cell differentiation Cell signaling Immune response Synaptic plasticity Cell cycle regulation Transcriptional regulation Signal transduction Thermoregulation Cellular response to stress Hormonal regulation Neurotransmitter release Cellular response to DNA damage Cellular response to growth factors Lipid metabolism Protein metabolism Glucose metabolism Stress response Neurodevelopment Bone metabolism Energy homeostasis Cellular response to hypoxia Cellular response to inflammation Cellular response to mechanical stress Cellular response to oxidative stress Cellular response to infection Cardiovascular function Cellular response to apoptosis signals Cellular response to chemical stress Cellular response to cytokines Cellular response to environmental stimuli Cellular response to hormones Cellular response to metabolic stress Cellular response to nutrients Cellular response to radiation Cellular response to thermal stress Circadian rhythm Reproductive function |
| gptkbp:is_part_of |
Thyroid hormone signaling pathway
|
| gptkbp:is_regulated_by |
Nuclear receptor coactivators
Nuclear receptor corepressors |
| gptkbp:location |
gptkb:Atom
|
| gptkbp:promoter |
THRA
THRB |
| gptkbp:related_products |
Thyroid hormones
|
| gptkbp:role |
Development
|
| gptkbp:targets |
Thyroid hormone replacement therapy
Antithyroid drugs |
| gptkbp:type |
gptkb:fusion
|
| gptkbp:bfsParent |
gptkb:Ronald_Evans
|
| gptkbp:bfsLayer |
5
|