|
gptkbp:instanceOf
|
nuclear receptor
|
|
gptkbp:activatedBy
|
gptkb:T3
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:binds
|
gptkb:triiodothyronine_(T3)
hormone
thyroxine (T4)
|
|
gptkbp:discoveredIn
|
1986
|
|
gptkbp:domain
|
DNA-binding domain
ligand-binding domain
|
|
gptkbp:EC_number
|
3.1.3.48
|
|
gptkbp:encodedBy
|
THRB gene
THRA gene
|
|
gptkbp:expressedIn
|
gptkb:pituitary_gland
gptkb:skeletal_muscle
gptkb:kidney
brain
heart
liver
thyroid gland
|
|
gptkbp:form
|
heterodimer with retinoid X receptor
|
|
gptkbp:foundIn
|
gptkb:nucleus
|
|
gptkbp:function
|
DNA binding
transcription factor activity
hormone receptor activity
|
|
gptkbp:hasHGNC
|
11797
11799
|
|
gptkbp:hasUniProt
|
P10828
P10827
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Thyroid hormone receptor
|
|
gptkbp:inhibitedBy
|
antagonists
|
|
gptkbp:involvedIn
|
development
differentiation
growth
metabolism regulation
|
|
gptkbp:locatedOnChromosome
|
chromosome 17 (THRA)
chromosome 3 (THRB)
|
|
gptkbp:memberOf
|
steroid hormone receptor superfamily
|
|
gptkbp:modulatedBy
|
transcription
|
|
gptkbp:molecularWeight
|
~48 kDa
|
|
gptkbp:OMIM
|
190160
190120
|
|
gptkbp:PDB
|
1NAX
1NAV
|
|
gptkbp:regulates
|
gene expression
|
|
gptkbp:significance
|
gptkb:thyroid_hormone_resistance
hypothyroidism
hyperthyroidism
|
|
gptkbp:subspecies
|
TRα
TRβ
|
|
gptkbp:bfsParent
|
gptkb:Nuclear_Receptor_(biochemistry)
|
|
gptkbp:bfsLayer
|
6
|