Peroxisome proliferator-activated receptor

URI: https://gptkb.org/entity/Peroxisome_proliferator-activated_receptor
GPTKB entity
Statements (40)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:abbreviation PPAR
gptkbp:associatedWith gptkb:type_2_diabetes
gptkb:metabolic_syndrome
obesity
atherosclerosis
gptkbp:binds gptkb:gene
gptkbp:category transcription factor
nuclear receptor
gptkbp:discoveredBy gptkb:Issemann_and_Green
gptkbp:discoveredIn 1990
gptkbp:expressedIn gptkb:skeletal_muscle
gptkb:kidney
heart
liver
adipose tissue
intestine
gptkbp:formsHeterodimerWith retinoid X receptor
gptkbp:function lipid metabolism
regulation of gene expression
glucose homeostasis
gptkbp:gene gptkb:PPARG
PPARA
PPARD
https://www.w3.org/2000/01/rdf-schema#label Peroxisome proliferator-activated receptor
gptkbp:ligand fatty acids
eicosanoids
gptkbp:location cell nucleus
gptkbp:member nuclear receptor superfamily
gptkbp:regulates inflammation
fatty acid oxidation
insulin sensitivity
adipogenesis
gptkbp:subspecies gptkb:PPAR-gamma
PPAR-alpha
PPAR-beta/delta
gptkbp:target gptkb:thiazolidinediones
fibrate drugs
gptkbp:bfsParent gptkb:Nuclear_Receptor_(biochemistry)
gptkbp:bfsLayer 6