Nuclear receptor superfamily
GPTKB entity
Statements (101)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
superfamily
|
| gptkbp:binds |
vitamins
hormones other signaling molecules |
| gptkbp:composedOf |
nuclear receptors
|
| gptkbp:contains |
gptkb:steroid_hormone_receptors
orphan nuclear receptors thyroid hormone receptors peroxisome proliferator-activated receptors retinoic acid receptors |
| gptkbp:containsGene |
gptkb:NR0B1
gptkb:NR4A1 gptkb:NR1I1 gptkb:NR4A2 gptkb:NR4A3 gptkb:NR3A1 gptkb:NR1H2 gptkb:NR1H3 gptkb:NR1B1 NR3C1 NR3C2 NR5A1 NR0B2 NR1A1 NR1C1 NR1D1 NR1F1 NR1H4 NR1I2 NR1I3 NR2A1 NR2B1 NR2C1 NR2C2 NR2E1 NR2E3 NR2F1 NR2F2 NR2F6 NR3B1 NR5A2 NR6A1 |
| gptkbp:discoveredBy |
gptkb:Pierre_Chambon
|
| gptkbp:discoveredIn |
1980s
|
| gptkbp:domain |
DNA-binding domain
ligand-binding domain |
| gptkbp:foundIn |
animals
humans |
| gptkbp:function |
transcription regulation
|
| gptkbp:hasMember |
gptkb:NR3_subfamily
gptkb:androgen_receptor estrogen receptor glucocorticoid receptor progesterone receptor mineralocorticoid receptor retinoid X receptor vitamin D receptor farnesoid X receptor liver X receptor AR receptor COUP-TF receptor DAX-1 receptor ER receptor ERR receptor GCR receptor HNF4 receptor LRH-1 receptor MR receptor NGFI-B receptor NR0 subfamily NR1 subfamily NR2 subfamily NR4 subfamily NR5 subfamily NR6 subfamily PPAR receptor PR receptor RAR receptor REV-ERB receptor ROR receptor RXR receptor SF-1 receptor SHR receptor TR receptor TR2 receptor TR4 receptor VDR receptor peroxisome proliferator-activated receptor alpha peroxisome proliferator-activated receptor delta peroxisome proliferator-activated receptor gamma |
| https://www.w3.org/2000/01/rdf-schema#label |
Nuclear receptor superfamily
|
| gptkbp:mechanismOfAction |
ligand-dependent transcription factor
ligand-independent transcription factor |
| gptkbp:regulates |
gene expression
|
| gptkbp:relatedTo |
development
homeostasis metabolism reproduction endocrine system |
| gptkbp:bfsParent |
gptkb:Nuclear_Receptor_(biochemistry)
|
| gptkbp:bfsLayer |
6
|