|
gptkbp:instanceOf
|
gptkb:protein
nuclear receptor
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:bone
gptkb:endometrial_cancer
|
|
gptkbp:discoveredBy
|
gptkb:Elwood_V._Jensen
|
|
gptkbp:discoveredIn
|
1958
|
|
gptkbp:encodedBy
|
gptkb:ESR2_gene
ESR1 gene
|
|
gptkbp:enemyOf
|
gptkb:fulvestrant
gptkb:tamoxifen
gptkb:estradiol
ethinylestradiol
diethylstilbestrol
|
|
gptkbp:foundIn
|
gptkb:fish
birds
amphibians
mammals
reptiles
|
|
gptkbp:function
|
regulates gene expression
binds estrogen hormones
|
|
gptkbp:GO_term
|
GO:0003707
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Estrogen receptor
|
|
gptkbp:ligand
|
gptkb:estradiol
estriol
estrone
|
|
gptkbp:locatedOnChromosome
|
14q23.2 (ESR2)
6q25.1 (ESR1)
|
|
gptkbp:location
|
gptkb:nucleus
gptkb:cytoplasm
|
|
gptkbp:molecularWeight
|
59 kDa (ERβ)
66 kDa (ERα)
|
|
gptkbp:OMIM
|
133430 (ESR1)
601663 (ESR2)
|
|
gptkbp:regulates
|
cell proliferation
central nervous system
cardiovascular system
reproductive system
bone density
|
|
gptkbp:structure
|
DNA-binding domain
ligand-binding domain
activation function domain
|
|
gptkbp:subspecies
|
ERα
ERβ
|
|
gptkbp:target
|
gptkb:fulvestrant
gptkb:tamoxifen
raloxifene
|
|
gptkbp:UniProtID
|
gptkb:P03372
|
|
gptkbp:bfsParent
|
gptkb:Nuclear_Receptor_(biochemistry)
|
|
gptkbp:bfsLayer
|
6
|