|
gptkbp:instanceOf
|
gptkb:nuclear_receptor
gptkb:protein
|
|
gptkbp:abbreviation
|
gptkb:RAR
|
|
gptkbp:activatedBy
|
gptkb:retinoic_acid
|
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gptkbp:associatedWith
|
gptkb:acute_promyelocytic_leukemia
|
|
gptkbp:binds
|
gptkb:retinoic_acid
|
|
gptkbp:discoveredIn
|
1987
|
|
gptkbp:encodedBy
|
RARA gene
RARB gene
RARG gene
|
|
gptkbp:formsHeterodimerWith
|
retinoid X receptor
|
|
gptkbp:foundIn
|
vertebrates
|
|
gptkbp:function
|
regulation of gene expression
|
|
gptkbp:has_clinical_relevance
|
gptkb:cancer
dermatology
developmental disorders
|
|
gptkbp:hasIsoform
|
gptkb:RAR-alpha
RAR-beta
RAR-gamma
|
|
gptkbp:interactsWith
|
coactivators
corepressors
|
|
gptkbp:involvedIn
|
gptkb:immune_response
apoptosis
cell differentiation
embryonic development
|
|
gptkbp:ligand
|
gptkb:9-cis-retinoic_acid
all-trans-retinoic acid
|
|
gptkbp:locatedOnChromosome
|
chromosome 12 (RARG)
chromosome 17 (RARA)
chromosome 3 (RARB)
|
|
gptkbp:location
|
cell nucleus
|
|
gptkbp:memberOf
|
nuclear hormone receptor superfamily
|
|
gptkbp:modulatedBy
|
transcription of target genes
|
|
gptkbp:orthologIn
|
mouse Rar genes
zebrafish Rar genes
|
|
gptkbp:PDB
|
1XAP
|
|
gptkbp:regulates
|
gptkb:HOX_genes
apoptosis
cell proliferation
cellular differentiation
retinoic acid response elements (RAREs)
|
|
gptkbp:structure
|
DNA-binding domain
ligand-binding domain
|
|
gptkbp:subclassOf
|
gptkb:transcription_factor
|
|
gptkbp:target
|
retinoid drugs
|
|
gptkbp:UniProtID
|
P10276 (RARA)
P10826 (RARB)
P13631 (RARG)
|
|
gptkbp:bfsParent
|
gptkb:Nuclear_Receptor_(biochemistry)
|
|
gptkbp:bfsLayer
|
6
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Retinoic acid receptor
|