Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
gptkb:protein
nuclear receptor |
| gptkbp:abbreviation |
gptkb:RAR
|
| gptkbp:activatedBy |
retinoic acid
|
| gptkbp:associatedWith |
gptkb:acute_promyelocytic_leukemia
|
| gptkbp:binds |
retinoic acid
|
| gptkbp:discoveredIn |
1987
|
| gptkbp:encodedBy |
RARA gene
RARB gene RARG gene |
| gptkbp:formsHeterodimerWith |
retinoid X receptor
|
| gptkbp:foundIn |
vertebrates
|
| gptkbp:function |
regulation of gene expression
|
| gptkbp:has_clinical_relevance |
gptkb:cancer
dermatology developmental disorders |
| gptkbp:hasIsoform |
gptkb:RAR-alpha
RAR-beta RAR-gamma |
| https://www.w3.org/2000/01/rdf-schema#label |
Retinoic acid receptor
|
| gptkbp:interactsWith |
coactivators
corepressors |
| gptkbp:involvedIn |
apoptosis
cell differentiation embryonic development immune response |
| gptkbp:ligand |
gptkb:9-cis-retinoic_acid
all-trans-retinoic acid |
| gptkbp:locatedOnChromosome |
chromosome 12 (RARG)
chromosome 17 (RARA) chromosome 3 (RARB) |
| gptkbp:location |
cell nucleus
|
| gptkbp:memberOf |
nuclear hormone receptor superfamily
|
| gptkbp:modulatedBy |
transcription of target genes
|
| gptkbp:orthologIn |
mouse Rar genes
zebrafish Rar genes |
| gptkbp:PDB |
1XAP
|
| gptkbp:regulates |
gptkb:HOX_genes
apoptosis cell proliferation cellular differentiation retinoic acid response elements (RAREs) |
| gptkbp:structure |
DNA-binding domain
ligand-binding domain |
| gptkbp:subclassOf |
transcription factor
|
| gptkbp:target |
retinoid drugs
|
| gptkbp:UniProtID |
P10276 (RARA)
P10826 (RARB) P13631 (RARG) |
| gptkbp:bfsParent |
gptkb:Nuclear_Receptor_(biochemistry)
|
| gptkbp:bfsLayer |
6
|