Statements (54)
Predicate | Object |
---|---|
gptkbp:instanceOf |
gptkb:protein
nuclear receptor |
gptkbp:activatedBy |
gptkb:dexamethasone
gptkb:prednisolone cortisol |
gptkbp:alias |
GR
NR3C1 |
gptkbp:discoveredBy |
gptkb:Elwood_V._Jensen
|
gptkbp:encodedBy |
NR3C1 gene
|
gptkbp:expressedIn |
most tissues
|
gptkbp:foundIn |
humans
mammals |
gptkbp:function |
regulates gene expression
binds glucocorticoids mediates anti-inflammatory effects |
gptkbp:HGNC_ID |
7978
|
https://www.w3.org/2000/01/rdf-schema#label |
Glucocorticoid receptor
|
gptkbp:inhibitedBy |
gptkb:RU-486
|
gptkbp:interactsWith |
heat shock proteins
coactivators corepressors glucocorticoid response elements |
gptkbp:locatedOnChromosome |
5q31-q32
|
gptkbp:location |
gptkb:nucleus
gptkb:cytoplasm |
gptkbp:mutationAssociatedWith |
gptkb:Cushing's_syndrome
Addison's disease glucocorticoid resistance |
gptkbp:OMIM |
138040
|
gptkbp:PDB |
1M2Z
4P6W |
gptkbp:phosphorylates |
Serine 211
Serine 226 |
gptkbp:regulates |
apoptosis
metabolism inflammation blood pressure immune response lipolysis bone metabolism stress response gluconeogenesis protein catabolism |
gptkbp:structure |
contains DNA-binding domain
contains ligand-binding domain contains transactivation domain |
gptkbp:targetOfDrug |
gptkb:cancer
autoimmune diseases inflammatory diseases allergic diseases |
gptkbp:UniProtID |
P04150
|
gptkbp:bfsParent |
gptkb:Nuclear_Receptor_(biochemistry)
gptkb:Corticosteroid |
gptkbp:bfsLayer |
6
|