Glucocorticoid receptor

GPTKB entity

Statements (54)
Predicate Object
gptkbp:instanceOf gptkb:protein
nuclear receptor
gptkbp:activatedBy gptkb:dexamethasone
gptkb:prednisolone
cortisol
gptkbp:alias GR
NR3C1
gptkbp:discoveredBy gptkb:Elwood_V._Jensen
gptkbp:encodedBy NR3C1 gene
gptkbp:expressedIn most tissues
gptkbp:foundIn humans
mammals
gptkbp:function regulates gene expression
binds glucocorticoids
mediates anti-inflammatory effects
gptkbp:HGNC_ID 7978
https://www.w3.org/2000/01/rdf-schema#label Glucocorticoid receptor
gptkbp:inhibitedBy gptkb:RU-486
gptkbp:interactsWith heat shock proteins
coactivators
corepressors
glucocorticoid response elements
gptkbp:locatedOnChromosome 5q31-q32
gptkbp:location gptkb:nucleus
gptkb:cytoplasm
gptkbp:mutationAssociatedWith gptkb:Cushing's_syndrome
Addison's disease
glucocorticoid resistance
gptkbp:OMIM 138040
gptkbp:PDB 1M2Z
4P6W
gptkbp:phosphorylates Serine 211
Serine 226
gptkbp:regulates apoptosis
metabolism
inflammation
blood pressure
immune response
lipolysis
bone metabolism
stress response
gluconeogenesis
protein catabolism
gptkbp:structure contains DNA-binding domain
contains ligand-binding domain
contains transactivation domain
gptkbp:targetOfDrug gptkb:cancer
autoimmune diseases
inflammatory diseases
allergic diseases
gptkbp:UniProtID P04150
gptkbp:bfsParent gptkb:Nuclear_Receptor_(biochemistry)
gptkb:Corticosteroid
gptkbp:bfsLayer 6