|
gptkbp:instanceOf
|
gptkb:protein
nuclear receptor
|
|
gptkbp:activatedBy
|
gptkb:progesterone
|
|
gptkbp:alternativeName
|
gptkb:PR
NR3C3
|
|
gptkbp:binds
|
gptkb:progesterone
|
|
gptkbp:biologicalProcess
|
DNA binding
transcription factor activity
|
|
gptkbp:domain
|
DNA-binding domain
transactivation domain
hormone-binding domain
|
|
gptkbp:encodedBy
|
PGR gene
|
|
gptkbp:expressedIn
|
gptkb:endometrium
gptkb:prostate
gptkb:testis
brain
breast tissue
|
|
gptkbp:foundIn
|
humans
mammals
|
|
gptkbp:function
|
mediates effects of progesterone
|
|
gptkbp:hasClinicalTest
|
immunohistochemistry for PR status
|
|
gptkbp:hasIsoform
|
PR-A
PR-B
|
|
gptkbp:HGNC_ID
|
8910
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Progesterone receptor
|
|
gptkbp:involvedIn
|
reproductive system regulation
breast cancer biology
|
|
gptkbp:ligand
|
gptkb:progesterone
progestins
|
|
gptkbp:locatedOnChromosome
|
11q22-q23
|
|
gptkbp:memberOf
|
gptkb:steroid_hormone_receptor_family
|
|
gptkbp:OMIM
|
607311
|
|
gptkbp:PDB
|
1A28
2OVH
4A2J
|
|
gptkbp:regulates
|
cell proliferation
differentiation
gene expression
immune response
|
|
gptkbp:significance
|
gptkb:endometrial_cancer
fertility
breast cancer prognosis
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:target
|
gptkb:mifepristone
hormone therapy
hormonal contraceptives
antiprogestins
selective progesterone receptor modulators
|
|
gptkbp:UniProtID
|
P06401
|
|
gptkbp:bfsParent
|
gptkb:Nuclear_Receptor_(biochemistry)
|
|
gptkbp:bfsLayer
|
6
|