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gptkbp:instanceOf
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gptkb:protein
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gptkbp:alsoKnownAs
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gptkb:NR4A1
nuclear receptor subfamily 4 group A member 1
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gptkbp:discoveredBy
|
1988
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gptkbp:encodedBy
|
NR4A1 gene
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gptkbp:Entrez_Gene_ID
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gptkb:ENSG00000105976
3164
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gptkbp:expressedIn
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gptkb:skeletal_muscle
neurons
immune cells
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gptkbp:family
|
nuclear receptor family
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gptkbp:function
|
transcription factor
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gptkbp:gene
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gptkb:NR4A1
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gptkbp:HGNC_ID
|
7970
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gptkbp:homologInRat
|
gptkb:Nr4a1
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|
https://www.w3.org/2000/01/rdf-schema#label
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Nur77
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gptkbp:interactsWith
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gptkb:Bcl-2
gptkb:RXR_(Retinoid_X_Receptor)
DNA response elements
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gptkbp:ligand
|
orphan receptor (no known endogenous ligand)
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gptkbp:locatedOnChromosome
|
chromosome 12q13
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gptkbp:location
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gptkb:nucleus
gptkb:cytoplasm
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gptkbp:modulatedBy
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lipid metabolism
mitochondrial function
glucose metabolism
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gptkbp:OMIM
|
600242
|
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gptkbp:organism
|
gptkb:Homo_sapiens
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gptkbp:orthologInMouse
|
gptkb:Nr4a1
|
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gptkbp:PDB
|
1YJE
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gptkbp:phosphorylates
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gptkb:protein_kinase_C
gptkb:protein_kinase_A
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gptkbp:regulates
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cell proliferation
gene expression
cell death
induced by cytokines
induced by stress
induced by growth factors
induced by T cell activation
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gptkbp:role
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gptkb:cancer
apoptosis
metabolism
inflammation
T cell receptor signaling
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gptkbp:significance
|
potential target in cancer therapy
potential target in inflammatory diseases
potential target in metabolic diseases
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gptkbp:structure
|
contains DNA-binding domain
contains ligand-binding domain
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gptkbp:subfamily
|
NR4A subfamily
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gptkbp:UniProtID
|
P22736
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gptkbp:bfsParent
|
gptkb:NR4A1
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gptkbp:bfsLayer
|
8
|