Statements (51)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
transcription factor
nuclear receptor |
| gptkbp:discoveredIn |
1990
|
| gptkbp:encodedBy |
RXRA gene
RXRB gene RXRG gene |
| gptkbp:formsHeterodimerWith |
Farnesoid X Receptor (FXR)
Liver X Receptor (LXR) Peroxisome Proliferator-Activated Receptor (PPAR) Retinoic Acid Receptor (RAR) Thyroid Hormone Receptor (TR) Vitamin D Receptor (VDR) |
| gptkbp:function |
transcriptional activation
regulation of gene expression DNA binding |
| gptkbp:GO |
gptkb:GO:0006355_(regulation_of_transcription,_DNA-templated)
GO:0003707 (steroid hormone receptor activity) GO:0004879 (nuclear receptor activity) |
| gptkbp:hasIsoform |
gptkb:RXR_alpha
gptkb:RXR_beta gptkb:RXR_gamma |
| https://www.w3.org/2000/01/rdf-schema#label |
RXR (Retinoid X Receptor)
|
| gptkbp:ligand |
gptkb:9-cis-retinoic_acid
|
| gptkbp:locatedIn |
gptkb:nucleus
|
| gptkbp:locatedOnChromosome |
1q22 (RXRG)
6p21.3 (RXRB) 9q34.2 (RXRA) |
| gptkbp:PDB |
1FBY
1LBD |
| gptkbp:regulates |
apoptosis
cell differentiation development metabolism |
| gptkbp:species |
gptkb:Mus_musculus
gptkb:Homo_sapiens |
| gptkbp:subunit |
RXR-FXR heterodimer
RXR-LXR heterodimer RXR-PPAR heterodimer RXR-RAR heterodimer RXR-TR heterodimer RXR-VDR heterodimer |
| gptkbp:target |
gptkb:alitretinoin
gptkb:bexarotene LG100268 SR11237 |
| gptkbp:UniProtID |
gptkb:P19793_(RXRA)
P28702 (RXRB) P48443 (RXRG) |
| gptkbp:bfsParent |
gptkb:RARB
gptkb:NR1H2 |
| gptkbp:bfsLayer |
7
|