|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:activatedBy
|
phosphorylation
calcium signaling
|
|
gptkbp:alsoKnownAs
|
gptkb:TR3
gptkb:NR4A1
gptkb:Nur77
|
|
gptkbp:discoveredIn
|
rat PC12 cells
|
|
gptkbp:encodedBy
|
NR4A1 gene
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:ENSG00000105976
3164
|
|
gptkbp:expressedIn
|
gptkb:adrenal_gland
gptkb:thymus
brain
immune cells
|
|
gptkbp:firstDescribed
|
1988
|
|
gptkbp:function
|
apoptosis
cell proliferation
transcription factor
regulation of gene expression
metabolic regulation
T cell receptor signaling
|
|
gptkbp:gene
|
gptkb:NR4A1
|
|
gptkbp:HGNC_ID
|
7989
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NGFI-B
|
|
gptkbp:inducedBy
|
gptkb:nerve_growth_factor
stress
inflammatory signals
|
|
gptkbp:locatedOnChromosome
|
12q13
|
|
gptkbp:memberOf
|
nuclear receptor family
NR4A subfamily
|
|
gptkbp:orthologIn
|
gptkb:NR4A1
|
|
gptkbp:orthologInMouse
|
gptkb:Nr4a1
|
|
gptkbp:PDB
|
1YJE
|
|
gptkbp:regulates
|
gptkb:Bcl-2_family_proteins
inflammatory response
metabolic genes
cellular proliferation
Fas ligand expression
apoptosis in thymocytes
|
|
gptkbp:relatedTo
|
gptkb:cancer
gptkb:acute_myeloid_leukemia
gptkb:metabolic_syndrome
atherosclerosis
T cell development
|
|
gptkbp:structure
|
contains DNA-binding domain
contains ligand-binding domain
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
mitochondria (under certain conditions)
|
|
gptkbp:UniProtID
|
P22736
|
|
gptkbp:bfsParent
|
gptkb:NR4A1
|
|
gptkbp:bfsLayer
|
8
|