Nuclear receptor subfamily 4 group A member 1 protein

URI: https://gptkb.org/entity/Nuclear_receptor_subfamily_4_group_A_member_1_protein
GPTKB entity
Statements (50)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alternativeName gptkb:TR3
gptkb:NGFI-B
gptkb:Nur77
Nerve growth factor IB
gptkbp:associatedWith gptkb:cancer
gptkb:metabolic_syndrome
autoimmune disease
gptkbp:biologicalProcess transcription regulation
DNA binding
gptkbp:discoveredBy 1988
gptkbp:encodedBy NR4A1 gene
gptkbp:Entrez_Gene_ID gptkb:ENSG00000105976
3164
gptkbp:expressedIn gptkb:adrenal_gland
gptkb:thymus
brain
liver
spleen
gptkbp:family nuclear receptor family
gptkbp:function transcription factor
gptkbp:HGNC_ID 7981
https://www.w3.org/2000/01/rdf-schema#label Nuclear receptor subfamily 4 group A member 1 protein
gptkbp:interactsWith gptkb:Bcl-2
gptkb:RXR_(Retinoid_X_receptor)
HDACs
p300/CBP
gptkbp:length 598 amino acids
gptkbp:locatedOnChromosome 12q13
gptkbp:location gptkb:nucleus
gptkbp:OMIM 139313
gptkbp:organism gptkb:Homo_sapiens
gptkbp:orthologIn gptkb:Danio_rerio
gptkb:Mus_musculus
gptkb:Rattus_norvegicus
gptkbp:PDB 1YJE
gptkbp:postTranslationalModification phosphorylation
sumoylation
acetylation
gptkbp:regulates cell differentiation
cell proliferation
immune response
gptkbp:role apoptosis
inflammation
metabolic regulation
T cell receptor signaling
gptkbp:subfamily gptkb:NR4A
gptkbp:UniProtID P22736
gptkbp:bfsParent gptkb:NR4A1
gptkbp:bfsLayer 8