|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:non-small_cell_lung_cancer
gptkb:glioblastoma
colorectal cancer
|
|
gptkbp:biologicalProcess
|
cell differentiation
cell proliferation
signal transduction
|
|
gptkbp:cellularComponent
|
gptkb:plasma_membrane
|
|
gptkbp:domain
|
transmembrane domain
extracellular ligand-binding domain
tyrosine kinase domain
|
|
gptkbp:encodedBy
|
gptkb:EGFR_gene
|
|
gptkbp:Entrez_Gene_ID
|
1956
|
|
gptkbp:function
|
receptor tyrosine kinase involved in cell proliferation and differentiation
|
|
gptkbp:GO
|
gptkb:GO:0005006
GO:0005524
GO:0004672
|
|
gptkbp:hasIsoform
|
gptkb:EGFR_protein
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NP 004682.2
|
|
gptkbp:inhibitedBy
|
gptkb:afatinib
gptkb:erlotinib
gptkb:gefitinib
gptkb:osimertinib
|
|
gptkbp:length
|
1210 amino acids
|
|
gptkbp:ligand
|
gptkb:epidermal_growth_factor_(EGF)
gptkb:transforming_growth_factor_alpha_(TGF-α)
|
|
gptkbp:locatedOnChromosome
|
gptkb:7p11.2
|
|
gptkbp:location
|
gptkb:cell_membrane
cell surface
|
|
gptkbp:molecularWeight
|
134 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:L858R
gptkb:T790M
exon 19 deletion
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologIn
|
mouse Egfr protein
|
|
gptkbp:pathway
|
gptkb:JAK-STAT_signaling_pathway
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
|
|
gptkbp:PDB
|
1M17
2GS6
3POZ
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:protein_name
|
Epidermal growth factor receptor isoform 1 precursor
|
|
gptkbp:RefSeq
|
gptkb:NP_004682.2
NM_005228.5
|
|
gptkbp:reviewedBy
|
yes
|
|
gptkbp:signalPeptide
|
present
|
|
gptkbp:significance
|
target for cancer therapy
|
|
gptkbp:subunit
|
monomer, forms homodimers or heterodimers upon ligand binding
|
|
gptkbp:UniProtID
|
P00533-1
|
|
gptkbp:bfsParent
|
gptkb:O60216
|
|
gptkbp:bfsLayer
|
7
|