|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:Breast_cancer_type_1_susceptibility_protein
BRCA1_HUMAN
|
|
gptkbp:associatedWith
|
gptkb:cancer
gptkb:hereditary_breast_and_ovarian_cancer_syndrome
|
|
gptkbp:biologicalProcess
|
ubiquitin-protein transferase activity
DNA binding
cell cycle checkpoint
DNA double-strand break repair
|
|
gptkbp:cellularComponent
|
nuclear envelope
nucleoplasm
|
|
gptkbp:domain
|
gptkb:BRCT_domain
RING finger domain
|
|
gptkbp:encodedBy
|
gptkb:BRCA1_gene
|
|
gptkbp:Ensembl_Protein_ID
|
ENSP00000350283
|
|
gptkbp:Entrez_Gene_ID
|
672
|
|
gptkbp:function
|
DNA repair
tumor suppression
|
|
gptkbp:hasIsoform
|
gptkb:NP_009225
NP_009226
NP_009227
NP_009228
NP_009229
NP_009230
NP_009231
NP_009232
NP_009233
NP_009234
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
NP 000248
|
|
gptkbp:interactsWith
|
gptkb:CHEK2
gptkb:BARD1
gptkb:PALB2
gptkb:RAD51
ATM
|
|
gptkbp:length
|
1863 amino acids
|
|
gptkbp:locatedOnChromosome
|
17q21.31
|
|
gptkbp:molecularWeight
|
220 kDa
|
|
gptkbp:OMIM
|
113705
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:PDB
|
gptkb:1JM7
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
|
|
gptkbp:refersTo
|
human BRCA1 protein
|
|
gptkbp:RefSeq
|
gptkb:NP_000248
|
|
gptkbp:reviewedBy
|
gptkb:UniProtKB/Swiss-Prot
|
|
gptkbp:sequenceStatus
|
complete
|
|
gptkbp:subcellularLocation
|
gptkb:nucleus
|
|
gptkbp:UniProtID
|
P38398
|
|
gptkbp:bfsParent
|
gptkb:MYH7_(human)
|
|
gptkbp:bfsLayer
|
7
|