Statements (77)
| Predicate | Object |
|---|---|
| gptkbp:instance_of |
gptkb:DNA
|
| gptkbp:associated_with |
gptkb:Oncology
ovarian cancer |
| gptkbp:clinical_trial |
mutation analysis
|
| gptkbp:discovered_by |
researchers in 1996
|
| gptkbp:function |
tumor suppressor
|
| gptkbp:has_function |
DNA binding
protein binding |
| gptkbp:has_role |
apoptosis
cell cycle regulation |
| gptkbp:has_variants |
BARD1 mutations
|
| https://www.w3.org/2000/01/rdf-schema#label |
BARD1
|
| gptkbp:interacts_with |
gptkb:BRCA1
|
| gptkbp:involved_in |
DNA repair
|
| gptkbp:is_associated_with |
environmental factors
genetic predisposition tumor microenvironment chemoresistance radiation sensitivity prognosis in cancer patients |
| gptkbp:is_expressed_in |
various tissues
adipose tissue breast tissue lung tissue prostate tissue ovarian tissue skin tissue placental tissue testicular tissue |
| gptkbp:is_involved_in |
gptkb:embryonic_development
cell differentiation cell proliferation cellular homeostasis cellular metabolism chromatin remodeling immune response metabolic pathways signal transduction homologous recombination cellular response to stress cellular aging neurogenesis cellular communication cellular signaling vascular biology cellular repair mechanisms |
| gptkbp:is_linked_to |
gptkb:hereditary_breast_and_ovarian_cancer_syndrome
cellular stress response inflammation tumorigenesis cellular differentiation metastasis hormonal regulation cellular signaling networks |
| gptkbp:is_part_of |
gptkb:BRCA1-BARD1_complex
DNA damage response pathway nuclear processes cellular signaling pathways protein complexes |
| gptkbp:is_regulated_by |
gptkb:BRCA1
|
| gptkbp:is_studied_for |
clinical trials
therapeutic interventions pharmacogenomics therapeutic targets molecular mechanisms biomarker potential diagnostic markers |
| gptkbp:is_studied_in |
cancer research
genetic counseling |
| gptkbp:is_targeted_at |
gptkb:gene_therapy
therapeutic drugs |
| gptkbp:located_in |
human chromosome 2
|
| gptkbp:orthologs |
gptkb:mouse
zebrafish rat |
| gptkbp:bfsParent |
gptkb:BRCA1-BARD1_complex
|
| gptkbp:bfsLayer |
7
|