Breast cancer type 1 susceptibility protein

URI: https://gptkb.org/entity/Breast_cancer_type_1_susceptibility_protein
GPTKB entity
Statements (41)
Predicate Object
gptkbp:instanceOf gptkb:protein
gptkbp:alsoKnownAs gptkb:BRCA1
gptkbp:associatedSyndrome gptkb:Hereditary_Breast_and_Ovarian_Cancer_Syndrome
gptkbp:clinicalTrialPhase BRCA1 genetic testing
gptkbp:discoveredBy gptkb:Mary-Claire_King
gptkbp:discoveredIn 1990
gptkbp:encodedBy gptkb:BRCA1_gene
gptkbp:foundIn gptkb:Homo_sapiens
gptkbp:function DNA repair
tumor suppression
cell cycle checkpoint control
gptkbp:gene gptkb:BRCA1
https://www.w3.org/2000/01/rdf-schema#label Breast cancer type 1 susceptibility protein
gptkbp:interactsWith gptkb:CtIP
gptkb:BARD1
gptkb:PALB2
gptkb:p53
gptkb:RAD51
gptkbp:locatedOnChromosome gptkb:17q21
gptkbp:molecularWeight 220 kDa
gptkbp:mutationAssociatedWith gptkb:cancer
gptkbp:OMIM 113705
gptkbp:orthologIn gptkb:Mus_musculus
gptkb:Pan_troglodytes
gptkb:Canis_lupus_familiaris
gptkbp:PDB gptkb:1JM7
gptkbp:postTranslationalModification phosphorylation
ubiquitination
gptkbp:reviewedBy gptkb:Nature
gptkb:science
Cell
gptkbp:role homologous recombination
transcriptional regulation
genomic stability
ubiquitin ligase activity
gptkbp:structure contains BRCT domain
contains RING finger domain
gptkbp:subcellularLocation gptkb:nucleus
gptkbp:UniProtID P38398
gptkbp:bfsParent gptkb:HGNC:1097
gptkbp:bfsLayer 6