|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alias
|
gptkb:c-Myc
MYC proto-oncogene protein
|
|
gptkbp:associatedWith
|
gptkb:neuroblastoma
gptkb:Burkitt_lymphoma
gptkb:cancer
Small Cell Lung Cancer
|
|
gptkbp:binds
|
E-box DNA sequence
|
|
gptkbp:degradedBy
|
FBW7
|
|
gptkbp:discoveredBy
|
gptkb:Harold_Varmus
gptkb:J._Michael_Bishop
|
|
gptkbp:discoveredIn
|
1979
|
|
gptkbp:encodedBy
|
gptkb:MYC_gene
|
|
gptkbp:expressedIn
|
various tissues
|
|
gptkbp:formsComplexWith
|
gptkb:MAX_protein
|
|
gptkbp:foundIn
|
gptkb:Mus_musculus
gptkb:Homo_sapiens
|
|
gptkbp:function
|
transcription factor
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Myc protein
|
|
gptkbp:inhibitedBy
|
small molecule inhibitors
Omomyc
|
|
gptkbp:locale
|
gptkb:nucleus
|
|
gptkbp:locatedOnChromosome
|
chromosome 8q24
|
|
gptkbp:molecularWeight
|
~49 kDa
|
|
gptkbp:OMIM
|
190080
|
|
gptkbp:overexpressedIn
|
tumorigenesis
|
|
gptkbp:PDB
|
1NKP
|
|
gptkbp:phosphorylates
|
gptkb:GSK3
gptkb:CDK2
|
|
gptkbp:postTranslationalModification
|
phosphorylation
ubiquitination
acetylation
|
|
gptkbp:proteinFamily
|
basic helix-loop-helix leucine zipper (bHLH-LZ)
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
metabolism
cellular senescence
angiogenesis
cell growth
cell migration
DNA replication
immune response
cell cycle
cell adhesion
ribosome biogenesis
stem cell self-renewal
|
|
gptkbp:target
|
therapeutic research
|
|
gptkbp:UniProtID
|
P01106
|
|
gptkbp:bfsParent
|
gptkb:oncogene_c-myc
|
|
gptkbp:bfsLayer
|
8
|