Statements (52)
| Predicate | Object |
|---|---|
| gptkbp:instanceOf |
tumor suppressor
|
| gptkbp:alsoKnownAs |
gptkb:MYC
|
| gptkbp:discoveredBy |
gptkb:Bishop_and_Varmus
|
| gptkbp:discoveredIn |
1979
|
| gptkbp:encodes |
gptkb:Myc_protein
|
| gptkbp:function |
transcription factor
|
| gptkbp:gene |
gptkb:MYC
|
| gptkbp:geneType |
tumor suppressor
|
| https://www.w3.org/2000/01/rdf-schema#label |
oncogene c-myc
|
| gptkbp:involvedIn |
gptkb:cancer
|
| gptkbp:locatedOnChromosome |
gptkb:8q24
|
| gptkbp:mutationAssociatedWith |
translocation
amplification |
| gptkbp:organism |
gptkb:Homo_sapiens
|
| gptkbp:overexpressedIn |
gptkb:Burkitt_lymphoma
gptkb:cancer colorectal cancer leukemia |
| gptkbp:proteinFamily |
basic helix-loop-helix leucine zipper (bHLH-LZ)
|
| gptkbp:regulates |
apoptosis
cell differentiation cell proliferation DNA repair lipid metabolism metabolism cellular senescence angiogenesis cell cycle progression cell growth cell migration DNA replication glucose metabolism immune response oxidative phosphorylation chromatin structure histone modification stem cell maintenance glycolysis cellular metabolism cell adhesion mitochondrial biogenesis ribosome biogenesis nucleotide metabolism microRNAs glutamine metabolism |
| gptkbp:target |
gptkb:siRNA
antisense oligonucleotides small molecule inhibitors |
| gptkbp:translocationChromosome |
gptkb:chromosome_14
|
| gptkbp:translocationPartner |
gptkb:immunoglobulin_heavy_chain_gene
|
| gptkbp:bfsParent |
gptkb:Oncomouse
|
| gptkbp:bfsLayer |
7
|