|
gptkbp:instanceOf
|
gptkb:gene
tumor suppressor
|
|
gptkbp:alias
|
gptkb:c-Myc
gptkb:MYCC
gptkb:bHLHe39
gptkb:v-Myc
|
|
gptkbp:associatedWith
|
gptkb:Burkitt_lymphoma
multiple cancers
|
|
gptkbp:binds
|
E-box DNA sequence
|
|
gptkbp:discoveredBy
|
gptkb:Phillip_Leder
|
|
gptkbp:encodes
|
gptkb:c-Myc_protein
|
|
gptkbp:Entrez_Gene_ID
|
4609
|
|
gptkbp:expressedIn
|
gptkb:nucleus
|
|
gptkbp:firstDescribed
|
1979
|
|
gptkbp:formsComplexWith
|
gptkb:MAX_protein
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:HGNC_ID
|
7553
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MYC proto-oncogene
|
|
gptkbp:involvedIn
|
gptkb:MAPK_signaling_pathway
gptkb:PI3K-Akt_signaling_pathway
gptkb:Wnt_signaling_pathway
cellular response to hypoxia
|
|
gptkbp:length
|
439 amino acids
3 exons
|
|
gptkbp:locatedOnChromosome
|
chromosome 8
8q24.21
|
|
gptkbp:OMIM
|
190080
|
|
gptkbp:orthologInMouse
|
gptkb:Myc
|
|
gptkbp:overexpressedIn
|
tumorigenesis
|
|
gptkbp:phosphorylates
|
gptkb:Ser62
Thr58
|
|
gptkbp:proteinFamily
|
transactivation domain
nuclear localization signal
basic helix-loop-helix leucine zipper (bHLH-LZ)
|
|
gptkbp:regulates
|
apoptosis
cell differentiation
yes
transcription
metabolism
cellular senescence
angiogenesis
cell growth
DNA replication
cell cycle
cell adhesion
ribosome biogenesis
|
|
gptkbp:target
|
gptkb:siRNA
gptkb:CRISPR/Cas9
small molecule inhibitors
microRNAs
|
|
gptkbp:UniProtID
|
P01106
|
|
gptkbp:bfsParent
|
gptkb:Myc
|
|
gptkbp:bfsLayer
|
6
|