|
gptkbp:instanceOf
|
gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:activatedBy
|
G protein signaling pathway
|
|
gptkbp:alternativeName
|
gptkb:OPRM1
MOR
|
|
gptkbp:binds
|
gptkb:morphine
gptkb:enkephalins
gptkb:beta-endorphin
amphetamine
fentanyl
endorphins
|
|
gptkbp:cause
|
constipation
respiratory depression
euphoria
analgesia
physical dependence
miosis
|
|
gptkbp:discoveredIn
|
1973
|
|
gptkbp:encodedBy
|
gptkb:OPRM1_gene
|
|
gptkbp:enemyOf
|
gptkb:naloxone
gptkb:buprenorphine
gptkb:naltrexone
|
|
gptkbp:expressedIn
|
gptkb:spinal_cord
brain
gastrointestinal tract
immune cells
|
|
gptkbp:foundIn
|
gptkb:human
gptkb:mouse
right
|
|
gptkbp:has3DStructure
|
PDB:4DKL
|
|
gptkbp:hasPolymorphism
|
A118G
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Mu opioid receptor
|
|
gptkbp:inhibitedBy
|
gptkb:adenylate_cyclase
|
|
gptkbp:locatedIn
|
central nervous system
peripheral nervous system
|
|
gptkbp:locatedOnChromosome
|
6q24-q25
|
|
gptkbp:modulatedBy
|
phosphorylation
arrestin binding
receptor internalization
|
|
gptkbp:relatedTo
|
gptkb:nociceptin_receptor
delta opioid receptor
kappa opioid receptor
|
|
gptkbp:significance
|
pain management
opioid overdose
opioid addiction
|
|
gptkbp:subspecies
|
mu-1 receptor
mu-2 receptor
mu-3 receptor
|
|
gptkbp:UniProtID
|
gptkb:P35372
|
|
gptkbp:bfsParent
|
gptkb:Opioids
|
|
gptkbp:bfsLayer
|
7
|