|
gptkbp:instanceOf
|
gptkb:gene
|
|
gptkbp:A118G
|
rs1799971
|
|
gptkbp:A118G_effect
|
alters opioid sensitivity
associated with addiction risk
|
|
gptkbp:alias
|
MOR
MOR1
OPRM
OPRM1_HUMAN
|
|
gptkbp:associatedWith
|
alcohol dependence
opioid use disorder
pain sensitivity
response to naltrexone
|
|
gptkbp:chromosomeArm
|
q
|
|
gptkbp:discoveredBy
|
gptkb:Candace_Pert
|
|
gptkbp:encodes
|
gptkb:mu-opioid_receptor
|
|
gptkbp:Entrez_Gene_ID
|
4988
ENSG00000112038
|
|
gptkbp:expressedIn
|
gptkb:spinal_cord
brain
peripheral nervous system
|
|
gptkbp:fullName
|
opioid receptor mu 1
|
|
gptkbp:function
|
G-protein coupled receptor activity
opioid receptor activity
|
|
gptkbp:hasPolymorphism
|
A118G
|
|
gptkbp:HGNC_ID
|
HGNC:8156
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
OPRM1
|
|
gptkbp:involvedIn
|
addiction
pain modulation
respiratory depression
euphoria
analgesia
opioid dependence
opioid tolerance
reward pathway
|
|
gptkbp:locatedOnChromosome
|
6
6q24-q25
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:orthologInChimpanzee
|
gptkb:OPRM1
|
|
gptkbp:orthologInMouse
|
Oprm1
|
|
gptkbp:product
|
gptkb:mu-opioid_receptor
|
|
gptkbp:receptorFamily
|
gptkb:opioid_receptor_family
|
|
gptkbp:recipient
|
gptkb:G_protein-coupled_receptor
|
|
gptkbp:target
|
gptkb:methadone
gptkb:morphine
gptkb:enkephalins
gptkb:buprenorphine
gptkb:beta-endorphin
amphetamine
fentanyl
dynorphins
endogenous opioids
|
|
gptkbp:UniProtID
|
gptkb:P35372
|
|
gptkbp:bfsParent
|
gptkb:mu-opioid_receptor
|
|
gptkbp:bfsLayer
|
7
|