naloxone

GPTKB entity

Statements (65)
Predicate Object
gptkbp:instanceOf gptkb:drug
opioid
gptkbp:antidote heroin overdose
morphine overdose
fentanyl overdose
hydrocodone overdose
other opioid overdose
oxycodone overdose
gptkbp:approvedBy 1971
gptkbp:ATCCode V03AB15
gptkbp:bioavailability 100% (IV)
2% (oral)
35% (intranasal)
gptkbp:brand gptkb:Narcan
gptkb:Evzio
gptkbp:CASNumber 465-65-6
gptkbp:chemicalClass opioid
gptkbp:contraindication hypersensitivity to naloxone
gptkbp:developedBy gptkb:Janssen_Pharmaceutica
gptkbp:eliminationHalfLife 30–81 minutes
gptkbp:excretion urine
gptkbp:hasMolecularFormula C19H21NO4
https://www.w3.org/2000/01/rdf-schema#label naloxone
gptkbp:IUPACName gptkb:(5α)-4,5-Epoxy-3,14-dihydroxymorphinan-6-one
gptkbp:KEGGID D08367
gptkbp:legalStatus prescription only (US)
over-the-counter (US, some states)
gptkbp:mechanismOfAction delta-opioid receptor antagonist
kappa-opioid receptor antagonist
mu-opioid receptor antagonist
gptkbp:meltingPoint 200–205 °C
gptkbp:MeSH_ID D009294
gptkbp:metabolism liver
gptkbp:notEffectiveAgainst non-opioid overdose
gptkbp:pregnancyCategory B (US)
gptkbp:proteinBinding 45%
gptkbp:PubChem_CID 5284596
CHEMBL1044
DB01183
gptkbp:routeOfAdministration intramuscular
subcutaneous
intravenous
intranasal
gptkbp:sideEffect nausea
vomiting
hypertension
sweating
tachycardia
agitation
gptkbp:solubility soluble in water
gptkbp:UNII PBK1S1M032
gptkbp:usedFor opioid overdose
gptkbp:WHOModelListOfEssentialMedicines yes
gptkbp:bfsParent gptkb:Thebaine
gptkb:Heroin
gptkb:Buprenorphine
gptkb:Morphine
gptkb:Naltrexone
gptkb:Emergency_Medicine
gptkb:Narcan
gptkb:Anesthesia
gptkb:opioid
gptkb:Overdose
gptkb:buprenorphine
gptkbp:bfsLayer 6