|
gptkbp:instanceOf
|
gptkb:protein
gptkb:G_protein-coupled_receptor
|
|
gptkbp:alsoKnownAs
|
NOP receptor
ORL-1 receptor
|
|
gptkbp:associatedWith
|
gptkb:depression
pain modulation
substance abuse
anxiety disorders
|
|
gptkbp:discoveredIn
|
1994
|
|
gptkbp:doesNotBind
|
classical opioids
|
|
gptkbp:encodedBy
|
gptkb:OPRL1_gene
|
|
gptkbp:enemyOf
|
J-113397
Ro 64-6198
SCH 221510
UFP-101
|
|
gptkbp:Entrez_Gene_ID
|
4987
|
|
gptkbp:expressedIn
|
gptkb:spinal_cord
brain
|
|
gptkbp:foundIn
|
central nervous system
peripheral nervous system
|
|
gptkbp:function
|
regulation of mood
modulation of pain
regulation of reward pathways
|
|
gptkbp:HGNC_ID
|
OPRL1
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
nociceptin receptor
|
|
gptkbp:ligand
|
nociceptin
orphanin FQ
|
|
gptkbp:locatedIn
|
gptkb:cell_membrane
|
|
gptkbp:locatedOnChromosome
|
20q13.33
|
|
gptkbp:memberOf
|
gptkb:opioid_receptor_family
|
|
gptkbp:molecularWeight
|
40 kDa
|
|
gptkbp:OMIM
|
601495
|
|
gptkbp:orthologInMouse
|
Oprl1
|
|
gptkbp:PDB
|
4EA3
|
|
gptkbp:regulates
|
anxiety
stress response
nociception
addiction pathways
|
|
gptkbp:relatedTo
|
gptkb:delta-opioid_receptor
gptkb:kappa-opioid_receptor
gptkb:mu-opioid_receptor
|
|
gptkbp:transmembraneDomains
|
7
|
|
gptkbp:type
|
inhibits adenylate cyclase
activates potassium channels
inhibits calcium channels
|
|
gptkbp:UniProtID
|
P41146
|
|
gptkbp:bfsParent
|
gptkb:opioid
|
|
gptkbp:bfsLayer
|
6
|