|
gptkbp:instanceOf
|
gptkb:drug
|
|
gptkbp:broadcastOn
|
Schedule I (heroin in US)
Schedule II (most opioids in US)
Schedule III (buprenorphine in US)
Schedule IV (tramadol in US)
|
|
gptkbp:cause
|
gptkb:Euphoria
gptkb:Nausea
Addiction
Constipation
Tolerance
Respiratory depression
Physical dependence
|
|
gptkbp:enemyOf
|
gptkb:Naltrexone
gptkb:Naloxone
gptkb:Alvimopan
gptkb:Methylnaltrexone
gptkb:Nalmefene
|
|
gptkbp:epidemic
|
Opioid crisis
|
|
gptkbp:example
|
gptkb:Codeine
gptkb:Heroin
gptkb:Buprenorphine
gptkb:Hydrocodone
gptkb:Hydromorphone
gptkb:Meperidine
gptkb:Morphine
gptkb:Oxycodone
gptkb:Tapentadol
gptkb:Tramadol
gptkb:Methadone
gptkb:Loperamide
gptkb:Oxymorphone
gptkb:Dextromethorphan
Fentanyl
|
|
gptkbp:historicalPeriod
|
Used since ancient times
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Opioids
|
|
gptkbp:legalStatus
|
Controlled substance
|
|
gptkbp:mechanismOfAction
|
Bind to opioid receptors
|
|
gptkbp:naturalVariants
|
gptkb:Codeine
gptkb:Morphine
|
|
gptkbp:origin
|
gptkb:Opium_poppy
|
|
gptkbp:overdoseTreatment
|
gptkb:Naloxone
|
|
gptkbp:receptors
|
gptkb:Delta_opioid_receptor
gptkb:Kappa_opioid_receptor
gptkb:Mu_opioid_receptor
|
|
gptkbp:regulates
|
Prescription required
|
|
gptkbp:riskFactor
|
gptkb:Overdose
Withdrawal symptoms
Substance use disorder
|
|
gptkbp:routeOfAdministration
|
gptkb:Oral
Rectal
Intramuscular
Intravenous
Inhalation
Transdermal
Intranasal
Sublingual
|
|
gptkbp:semiSyntheticVariants
|
gptkb:Hydrocodone
gptkb:Oxycodone
|
|
gptkbp:sideEffect
|
gptkb:Hallucinations
gptkb:Bradycardia
Hypotension
Drowsiness
Dry mouth
Mood changes
Sexual dysfunction
Itching
Miosis
Endocrine dysfunction
Immune suppression
Impaired coordination
Suppressed cough reflex
Urinary retention
|
|
gptkbp:syntheticVariants
|
gptkb:Methadone
Fentanyl
|
|
gptkbp:usedFor
|
Pain management
Cough suppression
Diarrhea treatment
|
|
gptkbp:withdrawalSymptoms
|
gptkb:Nausea
gptkb:Anxiety
gptkb:Insomnia
Vomiting
Sweating
Muscle aches
Diarrhea
|
|
gptkbp:bfsParent
|
gptkb:Benzodiazepines
|
|
gptkbp:bfsLayer
|
6
|