|
gptkbp:instanceOf
|
gptkb:protein
|
|
gptkbp:alternativeName
|
gptkb:COX-2
gptkb:Prostaglandin_G/H_synthase_2
|
|
gptkbp:associatedWith
|
gptkb:Alzheimer's_disease
gptkb:cancer
inflammation
|
|
gptkbp:biologicalProcess
|
inflammatory response
heme binding
prostaglandin biosynthetic process
prostaglandin-endoperoxide synthase activity
|
|
gptkbp:Entrez_Gene_ID
|
gptkb:PTGS2
5743
ENSP00000226222
|
|
gptkbp:enzymeClassification
|
gptkb:EC_1.14.99.1
|
|
gptkbp:expression_induced_by
|
cytokines
growth factors
tumor promoters
|
|
gptkbp:function
|
catalyzes the conversion of arachidonic acid to prostaglandin H2
|
|
gptkbp:gene
|
gptkb:PTGS2
|
|
gptkbp:HGNC_ID
|
9605
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
P35372
|
|
gptkbp:inhibitedBy
|
gptkb:NSAIDs
gptkb:rofecoxib
gptkb:celecoxib
|
|
gptkbp:KEGGID
|
hsa:5743
|
|
gptkbp:length
|
604 amino acids
|
|
gptkbp:locatedOnChromosome
|
1q31.1
|
|
gptkbp:location
|
endoplasmic reticulum membrane
|
|
gptkbp:molecularWeight
|
69 kDa
|
|
gptkbp:OMIM
|
600262
|
|
gptkbp:organism
|
gptkb:Homo_sapiens
|
|
gptkbp:ortholog_in_chimpanzee
|
gptkb:PTGS2
|
|
gptkbp:orthologInMouse
|
Ptgs2
|
|
gptkbp:pathway
|
arachidonic acid metabolism
inflammatory mediator regulation of TRP channels
|
|
gptkbp:postTranslationalModification
|
phosphorylation
glycosylation
|
|
gptkbp:Reactome
|
R-HSA-211979
|
|
gptkbp:RefSeq
|
NP_000954.1
|
|
gptkbp:reviewed_in_UniProt
|
true
|
|
gptkbp:structure_available_in_PDB
|
5F19
1CVU
3LN1
|
|
gptkbp:subunit
|
homodimer
|
|
gptkbp:tissue_specificity
|
inducible in response to inflammatory stimuli
|
|
gptkbp:UniProtID
|
gptkb:P35372
|
|
gptkbp:bfsParent
|
gptkb:OPRM1_gene
gptkb:mu-opioid_receptor
|
|
gptkbp:bfsLayer
|
7
|