|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:actsOn
|
gptkb:tyramine
dopamine
norepinephrine
serotonin
epinephrine
|
|
gptkbp:alternativeName
|
MAO
amine oxidase (flavin-containing)
|
|
gptkbp:biologicalProcess
|
oxidoreductase activity
|
|
gptkbp:catalyzes
|
oxidative deamination of monoamines
|
|
gptkbp:clinical_use_of_inhibitors
|
antidepressants
treatment of Parkinson's disease
|
|
gptkbp:cofactor
|
gptkb:FAD_(flavin_adenine_dinucleotide)
|
|
gptkbp:discoveredBy
|
gptkb:Mary_Bernheim
|
|
gptkbp:discoveredIn
|
1928
|
|
gptkbp:EC_number
|
1.4.3.4
|
|
gptkbp:encodedBy
|
gptkb:MAOA_gene
gptkb:MAOB_gene
|
|
gptkbp:foundIn
|
gastrointestinal tract
liver
mitochondria
nervous tissue
|
|
gptkbp:hasIsoform
|
gptkb:MAO-A
gptkb:MAO-B
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
Monoamine oxidase
|
|
gptkbp:inhibitedBy
|
gptkb:monoamine_oxidase_inhibitors
increased monoamine levels
|
|
gptkbp:inhibitor_example
|
gptkb:isocarboxazid
gptkb:phenelzine
gptkb:tranylcypromine
gptkb:selegiline
|
|
gptkbp:locatedOnChromosome
|
X chromosome (MAOA)
X chromosome (MAOB)
|
|
gptkbp:presentIn
|
animals
humans
fungi
plants
|
|
gptkbp:regulates
|
levels of neurotransmitters
|
|
gptkbp:significance
|
gptkb:Parkinson's_disease
gptkb:depression
neurodegenerative diseases
anxiety disorders
psychiatric disorders
|
|
gptkbp:structure
|
dimeric protein
|
|
gptkbp:substrate
|
MAO-A prefers serotonin and norepinephrine
MAO-B prefers phenylethylamine and benzylamine
|
|
gptkbp:type
|
irreversible inhibitor
reversible inhibitor
|
|
gptkbp:bfsParent
|
gptkb:Dopamine_(in_brain)
|
|
gptkbp:bfsLayer
|
8
|