|
gptkbp:instanceOf
|
gptkb:enzyme
|
|
gptkbp:alternativeSplicing
|
yes
|
|
gptkbp:associatedWith
|
gptkb:depression
anxiety
aggression
antisocial behavior
|
|
gptkbp:cofactor
|
gptkb:FAD_(flavin_adenine_dinucleotide)
|
|
gptkbp:discoveredBy
|
gptkb:Mary_Bernheim
|
|
gptkbp:discoveredIn
|
1928
|
|
gptkbp:EC_number
|
1.4.3.4
|
|
gptkbp:encodedBy
|
gptkb:MAOA_gene
|
|
gptkbp:expressedIn
|
gptkb:cancer
gptkb:adrenal_gland
gptkb:kidney
gptkb:placenta
gptkb:small_intestine
brain
heart
liver
|
|
gptkbp:fullName
|
gptkb:Monoamine_oxidase_A
|
|
gptkbp:function
|
catalyzes the oxidative deamination of monoamines
|
|
gptkbp:gene
|
gptkb:MAOA
|
|
gptkbp:geneType
|
protein-coding
|
|
gptkbp:hasPolymorphism
|
uVNTR promoter polymorphism
|
|
gptkbp:HGNC_ID
|
6833
|
|
https://www.w3.org/2000/01/rdf-schema#label
|
MAO-A
|
|
gptkbp:inhibitedBy
|
gptkb:phenelzine
gptkb:tranylcypromine
gptkb:clorgyline
gptkb:moclobemide
|
|
gptkbp:length
|
approximately 60 kb
|
|
gptkbp:locatedOnChromosome
|
gptkb:X_chromosome
Xp11.3
|
|
gptkbp:location
|
outer mitochondrial membrane
|
|
gptkbp:molecularWeight
|
59 kDa
|
|
gptkbp:mutationAssociatedWith
|
gptkb:Brunner_syndrome
|
|
gptkbp:numberOfExons
|
15
|
|
gptkbp:OMIM
|
309850
|
|
gptkbp:orthologInMouse
|
gptkb:Maoa
|
|
gptkbp:PDB
|
2BXS
|
|
gptkbp:polymorphismEffect
|
affects enzyme activity
|
|
gptkbp:RefSeq
|
NM_000240
|
|
gptkbp:relatedTo
|
gptkb:MAO-B
|
|
gptkbp:significance
|
target for antidepressant drugs
target for anxiolytic drugs
target for treatment of Parkinson's disease
|
|
gptkbp:structure
|
dimer
|
|
gptkbp:substrate
|
gptkb:tyramine
dopamine
norepinephrine
serotonin
|
|
gptkbp:UniProtID
|
gptkb:P21397
|
|
gptkbp:bfsParent
|
gptkb:MAO_inhibitors
|
|
gptkbp:bfsLayer
|
6
|